Results 31 to 40 of about 183,671 (259)
The sexualisation of public space
Yhdyskuntasuunnittelu-lehti, 2019 Galanakis, M. (2019). The sexualisation of public space. Yhdyskuntasuunnittelu-Lehti, 57(4), 53-58.
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Demographic Groups’ Differences in Restorative Perception of Urban Public Spaces in COVID-19
Buildings, 2022 The health-promoting functions of one’s spatial environment have been widely recognized. Facing the huge loss of mental resources caused by the COVID-19 pandemic, visiting and perception of urban public spaces with restorative potential should be ...
Shiqi Wang, Ang Li
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Models for Positioning Public Spaces in the Metaverse
Journal of Technology in Architecture Design and PlanningThe Metaverse plane constitutes an ever-evolving virtual universe that encompasses various digital platforms. These platforms allow users to engage in diverse experiences and create virtual environments using technologies such as virtual reality ...
Ezgi Özkoç, Şan Yalçın Sarabil
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Conceptual commentary of public spaces in Durban, South Africa
Town and Regional Planning, 2018 Within the context of African cities that are considered to have poor economic prospects and are failing its inhabitants, this article explores and assesses the quality of Durban’s open public spaces through a phenomenological lens, by applying the ...
Magdalena Cloete, Salena Yusuf
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Public Space and Accessibility
Iconarp International J. of Architecture and Planning, 2018 Virtually everyone experiences a physical disability at some time in their lives; that is to say that their mobility has been restricted. An infant, en adult with an injury, a parent with a pushchair, an elderly person are all disabled in one way or another. Those who remain healthy and able-bodied throughout their lives are few.
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source