Results 81 to 90 of about 1,936,993 (296)
Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider +20 more
wiley +1 more source
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
New York State Campaign Finance Laws [PDF]
, 2009 Campaign finance laws govern how political candidates raise and spend monies for their elections. In general, there are three ways in which states regulate campaign finance: (1) disclosure, (2) contribution limits, and (3) public financing.
Fitzsimmons, Patrick
core +1 more source
Advanced Science, EarlyView.Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang +12 more
wiley +1 more source
Citizen Teacher: Damned If You Do, Damned If You Don\u27t [PDF]
, 2008 The recent Supreme Court case of Garcetti v. Ceballos is becoming one of the most-used cases in its mere two-year history. It denies to public employees the protection of the First Amendment when speaking in their official duties.
Stuart, Susan P.
core +2 more sources
Brazil: Modernity and Mobility [PDF]
, 2015 This essay examines the field of Brazilian mobility studies, concentrating mainly on recent (2010-2013) scholarship by Portuguese-speaking Brazilian academics published in English-language journals. The mass demonstrations and violent protests that have
Cooper, Martin
core +1 more source
Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans
Advanced Science, EarlyView.This study employs viral‐based single‐neuron tracing and dMRI‐based whole‐brain tractography to investigate arcuate fasciculus (AF) trajectories in macaque monkeys, and compares with the human AF connectome using spectral embedding. Results demonstrate conserved AF topography spanning temporoparietal‐auditory‐frontal pathways across primates, with ...
Jiahao Huang +17 more
wiley +1 more source
Open to the Public: Speaking Out on "No Child Left Behind", A Report from 2004 Public Hearings - New York [PDF]
, 2005 Shortly after NCLB was passed in 2001, Public Education Network (PEN) began an intensive examination of the law to determine the rights and privileges it accords to parents and community members.
core
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source