Results 161 to 170 of about 1,343,529 (302)

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Projections of Public Spending on Pharmaceuticals: A Review of Methods. [PDF]

Pharmacoeconomics
Odnoletkova I, Chalon PX, Devriese S, Cleemput I.   +3 more
europepmc   +1 more source

Public Spending on Health Services and Policy Research in Canada: A Reflection on Thakkar and Sullivan Comment on "Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal". [PDF]

Int J Health Policy Manag, 2018
Adams O.
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Who cares about childcare? Covid-19 and gender differences in local public spending. [PDF]

Int Tax Public Financ
Marchese A, Profeta P, Savio G.
europepmc   +1 more source

Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal. [PDF]

Int J Health Policy Manag, 2017
Thakkar V, Sullivan T.
europepmc   +1 more source

The composition of public expenditure and growth : a small-scale intertemporal model for low-income countries [PDF]

This paper presents a small-scale intertemporal model of endogenous growth that accounts for the composition of public expenditure and externalities associated with public capital.
Bayraktar, Nihal, Moreira, Emmanuel Pinto   +1 more
core  

HiST: Histological Images Reconstruct Tumor Spatial Transcriptomics via MultiScale Fusion Deep Learning

Advanced Science, EarlyView.
HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li, Dong Zhang, Eryu Peng, Shijun Shen, Hamid Alinejad‐Rokny, Yao Liu, Junke Zheng, Cizhong Jiang, Youqiong Ye   +8 more
wiley   +1 more source

Crowding in Private Quality: The Equilibrium Effects of Public Spending in Education. [PDF]

Q J Econ
Andrabi T, Bau N, Das J, Karachiwalla N, Khwaja AI.   +4 more
europepmc   +1 more source