Results 51 to 60 of about 68,089 (266)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The European Journal of Humour ResearchIn this article, which serves as an introduction to a special issue on humor and the public sphere, we argue that humor has become increasingly central to public discourse in the 21st century, and that this necessitates a rethinking of the relationship ...
Giselinde Kuipers, Dick Zijp
doaj +1 more source
TRENDS AND PROBLEMS OF THE PUBLIC SPHERE DEVELOPMENT IN RUSSIA
Дискурс, 2018 This article focuses on genesis and problems of the public sphere in Russia. The author concentrates on dysfunctional processes of the political public sphere development that prevent it from normal functioning.
V. А. Glukhikh, S. M. Elisejev
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Internet as a “Public Sphere”
Žurnalistikos Tyrimai, 2011 This paper considers the theory of the Internet becoming part of the “public sphere”. The first part of the paper looks at how the concept of the public sphere was used by different scholars and how they defined the theory of the “public sphere”.
Jurgita Matačinskaitė
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Noise Mapping, 2014 In 2014 the three-year interdisciplinary study SiRENE (Short and Long Term Effects of Traffic Noise Exposure) was launched in Switzerland. The goal of SiRENE is to investigate acute, short- and long-term e_ects of road, railway and aircraft noise ...
Karipidis Ioannis +7 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source