Results 121 to 130 of about 12,332,225 (304)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
An Analysis of Virtual Public Engagement in the Transportation Planning Process [PDF]
118420Public engagement is an important and required element of the transportation planning process. Since the onset of the COVID-19 pandemic, public engagement has shifted dramatically.
Dougald, Lance E +2 more
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
The transportation economy : just in time. [PDF]
DTRT06-G-0044The purpose of this project was to produce a short educational video, targeted at middle school and high school students, illustrating the critical role transportation plays in our modern economy.
Cole, Richard +2 more
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Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
This study surveyed Californians about their basic travel behavior patterns and opinions related to transportation, information that allows state leaders to align transportation plans and policies with public priorities.
Nixon, Hilary +3 more
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An eCertificate Program in Transportation Planning [PDF]
DTRT06-G-0044In this project, researchers developed a proposal to extend the delivery of the recently developedGraduate Certificate in Transportation Planning at Texas A&M University (TAMU) to a wider audience viadistance education (online or ...
Texas Transportation Institute. University Transportation Center for Mobility +2 more
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RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Since 1997, terrorists have focused much attention on public surface transportation as a target for attacks. Many of the plots have failed or been foiled, but those that have succeeded have resulted in large numbers of casualties and caused widespread ...
Trella, Joseph +2 more
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