Results 111 to 120 of about 1,670,878 (298)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
InfrastructuresThe objective of this research is to propose a public transport reorganization system that allows the improvement of urban vehicle flow. The lack of adequate transportation infrastructure and the existing disorder in the services provided by collective ...
Yessica Julia Verastegui, Doris Esenarro
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
California Voting and Suburbanization Patterns: Implications for Transit Policy, MTI Report 12-05 [PDF]
, 2013 Public transit is an environmentally friendly transportation mode that usually focuses on transporting people within and to the city center. However, over the last 60 years, population and employment has been suburbanizing.
Holian, Matthew J., Kahn, Matthew E.
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Working Toward Equality, Updated, Race, Employment, and Public Transportation in Erie County [PDF]
, 2017 As documented in the 2016 PPG report, “Working Toward Equality,” there are severe racial disparities in employment and earnings in Erie County. In this report, we update the data from the 2016 report and add new research and analysis about one important ...
Krolikowski, Aaron, Magavern, Sam
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IET Intelligent Transport SystemsThis study addresses the challenge of quantitatively assessing ride comfort in tram travel in Growing Urban Environments, where multiple influencing factors complicate developing a unified evaluation index system.
Xinhuan Zhang +4 more
doaj +1 more source
EULAR Rheumatology Open: Objectives: Patients with autoimmune rheumatic disease (ARD) frequently experience invisible yet disabling symptoms, including chronic pain, fatigue, mobility issues, sensory impairments, and cognitive dysfunction. These hidden disabilities can hinder
Faisal Parlindungan +12 more
doaj +1 more source
An Exploration of Transportation Terrorist Stabbing Attacks [PDF]
, 2019 In his August 22, 2018 message to supporters of the Islamic State of Iraq and [greater] Syria (ISIS), Abu Bakr al-Baghdadi implored ISIS fighters in Syria and Iraq as well as those on various jihadist fronts in Africa, the Middle East, and Asia not to be
Butterworth, Bruce R. +3 more
core +1 more source