Results 91 to 100 of about 12,332,225 (304)
Organic Transportation Networks: Human-Oriented Renewal of Modern Megapolises
ARCHive-SR, 2019 Studies related to the growth of the transportation networks from the second half of the 20th century have constantly been focused on the topological complexity of motorized & public transportation network (internal geometry & dynamics, occupied space ...
Oleksandr Galychyn +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Travel Satisfaction of Persons with Disabilities in Metropolitan Indonesia: A Case of Jakarta
Indonesian Journal of Disability StudiesMany studies have been conducted on travel satisfaction with public transportation in various countries. However, no studies have reached inclusive groups such as persons with disabilities, although most of them depend on public transportation ...
Husnul Fitri, Diah Rini Lesmawati
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
InfrastructuresThe objective of this research is to propose a public transport reorganization system that allows the improvement of urban vehicle flow. The lack of adequate transportation infrastructure and the existing disorder in the services provided by collective ...
Yessica Julia Verastegui, Doris Esenarro
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Integrating Transportation Management Companies (TMCs) and Public Transportation [PDF]
Emerging technologies have given rise to Transportation Management Companies (TMCs), which deliver on-demand services via a customer-facing smartphone app.
Ross, Catherine +4 more
core
IET Intelligent Transport SystemsThis study addresses the challenge of quantitatively assessing ride comfort in tram travel in Growing Urban Environments, where multiple influencing factors complicate developing a unified evaluation index system.
Xinhuan Zhang +4 more
doaj +1 more source