Results 81 to 90 of about 12,332,225 (304)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Finding Transportation Statistics

National Transportation Library (NTL) guide provides website links to resources related to the transportation industry. Includes statistics resources for general, multimodal, economic, highway, transit/rail, aviation and maritime ...
United States. Department of Transportation. National Transportation Library
core   +1 more source

ROUTE OPTIMIZATION OF URBAN PUBLIC TRANSPORTATION

Dyna, 2013
Este artículo muestra el proceso de optimización de rutas de transporte público urbano basado en las técnicas de investigación de operaciones. Éste muestra en el contorno del desarrollo e importancia de la planifi cación del transporte público colectivo ...
PATRICIA JARAMILLO-ÁLVAREZ, CARLOS A. GONZÁLEZ-CALDERÓN, GUILLERMO GONZÁLEZ-CALDERÓN   +2 more
doaj  

The roadmap and strategy for prioritizing the development of public transport in China

Multimodal Transportation
With the acceleration of urbanization and continuous population growth in China, transportation issues in central cities, especially large and mega-cities, have become increasingly prominent.
Jing Wang, Changjian Liu, Zhouhao Wu, Rufeng Liao, Gengze Li, Huapu Lu   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

From Attitude to Action: Exploring Factors Influencing Switching Behavior of Public Transport Users

Journal of Consumer Sciences
Background:  The number of vehicles in Denpasar has increased, while the public still hesitates to use public transportation, contributing to traffic congestion in Denpasar.
Ni Putu Cempaka Dharmadewi Atmaja, I Gusti Agung Ngurah Gede Eka Teja Kusuma, I Made Dauh Wijana   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Association Between Public Transportation Use and Loneliness Among Urban Elderly People Who Stop Driving

Gerontology and Geriatric Medicine, 2019
Aim: To examine the association between public transportation use and loneliness in urban elderly who stop driving. Methods: In this cross-sectional study, we assessed 31 community-dwelling older adults who had stopped driving.
Naoka Matsuda PT, MS, Shunsuke Murata PT, PhD, Kohtaroh Torizawa PT, MS, Tsunenori Isa PT, MS, Aoi Ebina PT, MS, Yuki Kondo PT, MS, Yamato Tsuboi PT, MS, Akimasa Fukuta PT, MS, Maho Okumura PT, MS, Chihiro Shigemoto PT, Rei Ono PT, MPH, PhD   +10 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source