Results 101 to 110 of about 12,387,034 (302)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Executive Pay in the Public Sector: The Case of CEOs in UK Universities [PDF]
We analyse top management public sector pay using a panel data of university Vice Chancellors (VC) in UK. We assess how institutional performance, hierarchical effects, and personal characteristics determine VC pay.
Ma, Ada, Peter Dolton
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Universities, conflict and the public sphere: trajectories of the public university in Lebanon
, 2021 Rarely examined through the prism of political theory, the public and private dimensions of universities tend to be defined in economistic terms of ‘who pays’ or ‘who benefits’, overlooking the political meanings of ‘public’ that relate to state-society relations and conditions of democracy.
openaire
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
In from the margins: development and internationalisation within Irish universities [PDF]
, 2009 Universities in Ireland, as elsewhere, are under severe pressure – indeed in crisis according to some commentators. The nature of this crisis is two-fold.
Gaynor, Niamh
core +1 more source
It's Time: The re-form of Australian public universities
, 2022 Universities matter - most of us can agree on that. They remain a vital, indispensable part of our society. What happens to them as a result of government policies, changing values and altered governance arrangements matters greatly, too.
Pelizzon, Alessandro +2 more
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source