Results 121 to 130 of about 17,475,868 (304)
Public values in the age of big data: A public information perspective
, 2019 Public administration scholars have so far largely viewed big data as a kind of technocratic transformation. However, through citizens’ digital records, use of service apps, social media, digital sensors, and other digital footprints, big data also gives
Ingrams, Alex; id_orcid +2 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Hinsdale South Homecoming Parade
, 1950 Hinsdale South students celebrate homecoming.
Indian Prairie Public Library
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Rights into Structures: Judging in a Time of Democratic Backsliding
German Law JournalThis article explores how the new generation of legalistic autocrats consolidates power—not by committing mass human rights violations as a way of consolidating power as authoritarians of the twentieth century did, but instead by attacking checks and ...
Kim Lane Scheppele
doaj +1 more source
Core values in public administration: Tools for openness and democracy? [Elektronisk resurs]
, 2019 This study presents core values at public authorities in Sweden and discusses them in relation to the legal foundation for the public administration. A corpus-based approach is allpied in order to overview the texts where the core values are presented ...
Nyström, Catharina,
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Ribbon acknowledging all who helped
, 1996 From the Darien Woman's Club to many other volunteers, residents worked hard to finally have a public library building to serve area ...
Indian Prairie Public Library
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Older people’s perspectives on frailty screening in primary care settings – a citizens’ jury study
BMC Primary CareBackground As the world’s population ages, there is a growing concern with frailty, marked by reduced strength and greater vulnerability to stress. Overcoming obstacles like reluctance towards screening methods in this process is crucial for identifying ...
Annette Braunack-Mayer +10 more
doaj +1 more source