Results 101 to 110 of about 11,306,497 (261)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

“We are Performance Philosophy Problems”: Towards an accessible Performance Philosophy? [PDF]

open access: yes
This article originates from a KeyGroup presentation at the June 2022 Performance Philosophy Problems conference in Helsinki in which the performers of Different Light Theatre Company, a learning-disabled theatre company based in Christchurch, New ...
Janet Gibson   +5 more
core   +1 more source

The Open Field of Performance Philosophy [PDF]

open access: yes, 2019
This editorial introduces issue 4.2 of the Performance Philosophy journal. As a culmination of an "open call" for proposals, this edition prompts the reflection, "What is open?" The editorial pursues that question in order to map the open field of ...
Will Daddario, Daddario, Will
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Control over lighting hampers performance

open access: yes, 1993
Aussi disponible en francais: Ma\ueetrise de l'\ue9clairage et performance ne vont pas de pairPeer reviewed: NoNRC publication ...
Veitch, J. A.
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Statistical models of publication basis in meta-analysis. [PDF]

open access: yes, 2000
PhDObjectives: To review, apply and compare existing publication bias methodology. To extend the selection model methods that adjust combined estimates and to develop models to adjust for publication bias and heterogeneity simultaneously.
Preston, Carrol Lesley
core   +3 more sources

Bibliometric Approach to Research Assessment: Publication Count, Citation Count, & Author Rank

open access: yesJournal of Information Science Theory and Practice, 2013
We investigated how bibliometric indicators such as publication count and citation count affect the assessment of research performance by computing various bibliometric scores of the works of Korean LIS faculty members and comparing the rankings by those
Yang, Kiduk, Lee, Jongwook
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Adjusting for Publication Bias in Meta-Analysis with Continuous Outcomes: A Comparative Study

open access: yesMathematics
Publication bias has been a problem facing meta-analysts. Methods adjusting for publication bias have been proposed in the literature. Comparative studies for methods adjusting for publication bias are found in the literature, but these studies are ...
Osama Almalik
doaj   +1 more source

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