Results 111 to 120 of about 1,036,441 (311)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Is Truth in Authority or Authority in Truth? Limitations to the Publication of Scientific Research [PDF]

open access: yes, 2012
This paper examines the limitations and potential bias that exist within efforts to publish articles in exercise physiology. By discussing perceptions that: (a) greater truth appears to exist based on the publishing authority or journal title, (b) that ...
Steele, James, Fisher, James
core  

[Publication performance of university orthopedic trauma surgery in Germany]. [PDF]

open access: yesChirurgie (Heidelb), 2022
Preut J   +3 more
europepmc   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Performance of lifeboats in ice

open access: yes, 2006
The performance of lifeboats in ice was evaluated using model scale boats in an ice tank. Performance in a range of ice conditions was determined using simple benchmarks. Three different lifeboat hull forms were tested, and two power levels were used for
Mak, L. M.   +5 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effects of Yogurt Supplementation on Feed Efficiency, Growth Performance, and Ileal Nutrient Digestibility in Broiler Chicken [PDF]

open access: yes
The use of probiotics, particularly fermented yogurt, in poultry diets has gained substantial interest due to their capacity to enhance growth performance, feed conversion efficiency, and nutrient absorption in broiler chickens.
Hoque, Ahasanul   +6 more
core   +1 more source

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