Results 161 to 170 of about 11,285,853 (344)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New and traditional energy resources from microbial activities in the agroindustrial system

open access: yesItalian Journal of Agronomy, 2009
Microbial processes leading to the production of energy from vegetable biomasses and from residues of the agroindustry make possible the exploitation of widely available and renewable energy sources which can be considered at zero balance with regard to ...
Roberto De Philippis   +1 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Folders 205-260: Publications. Articles and Books, 1950s [PDF]

open access: yes, 2011
Ramus, Method, and the Decay of Dialogue: Press copy. Typescript prepared for publisher includes annotations. First folder holds a memorandum to Harvard University Press.Items in these folders are from the Publications Sub-series—This sub-series is the ...
Ong, Walter J.
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Publication, publication, publication…

open access: yesThe Annals of The Royal College of Surgeons of England, 2014
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics

open access: yesDrug Design, Development and Therapy
Esther Ugo Alum,1 Sylvester Chibueze Izah,2 Daniel Ejim Uti,1 Okechukwu Paul-Chima Ugwu,1 Peter A Betiang,3 Mariam Basajja,4 Regina Idu Ejemot-Nwadiaro5 1Department of Research Publications, Kampala International University, Kampala, Uganda; 2Department ...
Alum EU   +6 more
doaj  

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