The Creation-Story of Genesis I: a Sumerian Theogony and Cosmogony. By DrHugo Radau. pp. xv and 70. (Chicago, Open Court Publishing Co.; London, Kegan Paul, Trench, Trübner, & Co., 1892.) [PDF]
T. G. Pinches
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
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Chemical Abstracts . Published by the American Chemical Society. Edited by William A. Noyes and C. A. Waters, with the cooperation of a large staff of assistant editors and abstractors. Published semi-monthly. Easton, Pa., Chemical Publishing Co. Vol. I., No. 1, January 1, 1907. Price, $6.00 per annum. [PDF]
Marston Taylor Bogert
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This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
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As urban aging issues intensify, the impact of the built environment in urban neighborhoods on the physical and mental health of elderly residents has garnered increasing attention. Previous studies have demonstrated that the built environment is related
Zhiguo Fang, Chenghao Jin, Cong Liu
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The Problem of Space in Jewish Medieval Philosophy. Israel Isaac Efros, Ph.D. Columbia University Press, 1917. Pp. viii, 125. $1.50. - Saadia's Polemic against Hiwi Al-Balkhi. Israel Davidson. Published by the Jewish Theological Seminary of America. A Fragment edited from a Genizah MS., with a Facsimile. New York. 1915. Pp. 104. $1.00. - Scrolls. Essays on Jewish History and Literature and Kindred Subjects. Gotthard Deutsch. 2 vols. Bloch Publishing Co.New York. 1917. [PDF]
Joshua Bloch
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
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Myths of Crete and Pre-Hellenic Europe. By Donald A. MacKenzie. Pp. 361, with 37 Plates (4 in colour). London: Gresham Publishing Co., 1917. [PDF]
Donald Alexander Mackenzie
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
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