Results 91 to 100 of about 550,257 (285)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The ethics of publishing

open access: yesSouth African Journal of Sports Medicine, 2013
The ethics of ...
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

දිවි තොර කරගැනීම් වාර්තාකරණය සහ මාධ්‍ය ආචාර ධර්ම

open access: yes, 2023
This entry includes 9 write-ups and 9 infographics (both in Sinhala)During the month of March 2023, several articles in Dinamina, Divaina, Ada, Mawbima, Lankadeepa and Daily Mirror published on suicide, which contained the following ethical violations ...
Ethics Eye
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Ethics in publishing [PDF]

open access: yesCanadian Urological Association Journal, 2012
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Ethics and decision making in publishing journal: Issues to be taken into account

open access: yes
One of the most prioritized questions of publishing a new journal in the almost similar fields covered by many other journals warrants certainly some clarification which needs to be addressed in the inaugural issue. A very straight response to this query
Safa, Mohammad Samaun
core  

Hermeneutics and moral imagination: the implications of Gadamer's truth and method for Christian ethics [PDF]

open access: yes, 2007
This study considers the implications for Christian ethics of the work of Hans-Georg Gadamer (in particular, his hermeneutics as presented in Truth and Method).
Wilson, Ashley Peter
core  

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