Results 81 to 90 of about 550,257 (285)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

සියදිවි හානිකරගැනීම් පිළිබ‍ඳ පුවත් වාර්තාකරණය: කෙතරම් දුරට සදාචාරාත්මකද?

open access: yes, 2020
This entry includes 15 write-ups and 16 infographics. (all in Sinhala)In November 2020, several newspapers (Aruna. Lankadeepa, Mawbima, Dinamina, Divaina) and news telecasts of TV channels (Hiru, Derana, ITN, Swarnavahini) reported news on suicide ...
Ethics Eye
core  

Publish ethically or perish

open access: yesJournal of Nature and Science of Medicine, 2019
The phrase “publish or perish” has been used in an academic context since the early 1970s to emphasize the importance of publishing the findings of research.
Arjumand S Warsy, Irfan Ahmad Warsy
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Conference Report: International Conference on Health Sciences and Medical Technologies, Tlemcen, Algeria 27–29 September 2016 ICHSMT’16

open access: yesElectronic Physician, 2016
The International Conference on Health Sciences and Medical Technologies (ICHSMT’16) was held in Tlemcen, Algeria from 27-29 September 2016. The conference was organized by the University Of Tlemcen, in partnership with Electronic Physician Journal ...
Abdeldjalil Khelassi
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Nature Writing and Publishing: The Ethics of a Cultural Mapping

open access: yesÉtudes Britanniques Contemporaines, 2018
This paper proposes to explore the recent popularity of nature writing in Britain as a means to mediate the existence of an ecosystem based on a specific ethics of writing, exploring, and publishing, through examples taken from recent works.
Cécile Beaufils
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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