Results 31 to 40 of about 460,499 (319)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

open access: yesAdvanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement   +12 more
wiley   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

open access: yesAdvanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang   +13 more
wiley   +1 more source

Population estimates of bat assemblages from hot caves in Puerto Rico

open access: yesNovitates Caribaea, 2023
Knowledge about the number of bats roosting in caves is critical for their long-term conservation. These roosts may function as shelter from weather or predators, information and social centers, or as nurseries.
Armando Rodríguez-Durán   +4 more
doaj   +1 more source

Livestock Tango: U.S. and Latin America Dance Together, but Who Will Lead?

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines the competitiveness between Latin American and U.S. livestock and meat sectors. We employ a computable general equilibrium modeling framework to evaluate two scenarios: coordinated improvements in Latin American productivity, transport efficiency, and market access (Scenario I), and the minimum productivity gains required ...
Taís C. Menezes   +2 more
wiley   +1 more source

Description of Patients Medications Needs and the Community Pharmacist’s Role in Puerto Rico Following a Natural Disaster

open access: yesJournal of Primary Care & Community Health, 2019
Background: In September 2017, Puerto Rico was hit by Hurricane Maria, a natural disaster that caused devastation. Initial reports of disruption to the health care system were later followed by increases in the death toll in Puerto Rico.
Beatriz C. Jiménez-Mangual   +4 more
doaj   +1 more source

Practice Variation Among Hispanic American Orthopedic Surgeons in the Management of Geriatric Distal Radius Fracture

open access: yesGeriatric Orthopaedic Surgery & Rehabilitation, 2020
Introduction: There is a controversy in the management of distal radius fractures (DRF) and its criteria for surgical intervention on geriatric patients. The American Academy of Orthopedic Surgeons (AAOS) developed evidence-based guidelines for treatment
Edwin G. Rosado MD   +9 more
doaj   +1 more source

Connecting Link Between Leptogenesis and Oscillations [PDF]

open access: yes, 2002
It is shown how, in a class of models, the sign of the baryon number of the universe can be related to CP violation in neutrino oscillation experiments.Comment: 5 pages LaTeX. Talk at the Third Tropical Workshop on Particles and Cosmology.
Frampton, Paul H.
core   +2 more sources

Medicaid Coverage and Utilization for Novel Therapies for Chronic Rhinosinusitis With Nasal Polyposis

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
Key Points Most state Medicaid programs granted omalizumab (91.4%) and dupilumab (59.5%) preferred drug status. Omalizumab was the most commonly prescribed therapy among Medicaid patients between 2015 and2024.
Eric R. Ramos   +7 more
wiley   +1 more source

Hotspots of Sequence Variability in Gut Microbial Genes Encoding Pro-Inflammatory Factors Revealed by Oligotyping

open access: yesFrontiers in Genetics, 2019
The gut microbiota has been implicated in a number of normal and disease biological processes. Recent studies have identified a subset of gut bacterial genes as potentially involved in inflammatory processes.
Ramón Gómez-Moreno   +8 more
doaj   +1 more source

Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models

open access: yesFrontiers in Oncology, 2023
BackgroundMetastatic disease lacks effective treatments and remains the primary cause of mortality from epithelial cancers, especially breast cancer.
Anamaris Torres-Sanchez   +9 more
doaj   +1 more source

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