Results 101 to 110 of about 15,600,345 (296)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2021 This is a sample submission generated by Vireo to test the repository deposit features.Test ...
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Pull-out strength of steel roof and wall cladding systems [PDF]
, 1998 When steel roof and wall cladding systems are subjected to wind uplift/suction forces, local pull-through/dimpling failures or pull-out failures occur prematurely at their screwed connections.
Mahendran, M., Tang, R.B.
core +1 more source
This is a sample submission generated by Vireo to test the repository deposit ...
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Centrifuge modelling of pile pull-out tests in expansive soil
, 2019 Designing foundations of wind turbines in expansive soils present a challenge. Piled foundations are often used to mitigate some of the problems associated with construction on expansive soils. Swelling clays frequently occur in an unsaturated state in many arid and semi-arid areas of the world.
Smit, G. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Optical investigation of crack initiation and propagation during the single fibre pull-out test
Results in MaterialsThe single fibre pull-out test is an important micromechanical test used to evaluate the fibre-matrix interface of polymer matrix composites primarily under shear stress.
Carol Winnifred Rodricks +1 more
doaj +1 more source