Results 101 to 110 of about 2,671,300 (345)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Slab pull, slab weakening, and their relation to deep intra-slab seismicity [PDF]

, 2005
Subduction zone seismicity is highly variable. Great earthquakes occur at few subduction zones around the world, with significant variation in size and frequency of deep events. Interactions between overriding and subducting plates and slab pull strength
Lithgow‐bertelloni, Carolina, Carolina Lithgow-bertelloni, Bilek, Susan L., Bilek, SL, Conrad, CP, Susan L. Bilek, Clinton P. Conrad, Lithgow-Bertelloni, C, Conrad, Clinton P.   +8 more
core   +1 more source

Zirconia crown design for pull-out test using a Universal testing machine.

, 2023
Zirconia crown design for pull-out test using a Universal testing machine.
Rawikorn Krongvanitchayakul (17283545), Chatchai Kunavisarut (9375036)   +1 more
core   +1 more source

Mechanical Pull-Out Test of a New Hybrid Fixture-Abutment Connection: An In Vitro Study. [PDF]

Materials (Basel), 2021
D'Addazio G, Sinjari B, Arcuri L, Femminella B, Murmura G, Santilli M, Caputi S.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Comparison between the pull-out test results and model predicted results for geotextiles.

, 2022
Comparison between the pull-out test results and model predicted results for geotextiles.
Fu Yi (11014577), Laigui Wang (12034789), Changbo Du (14014481), Ben Niu (1566001), Dongze Li (687236)   +4 more
core   +1 more source

Optical investigation of crack initiation and propagation during the single fibre pull-out test

Results in Materials
The single fibre pull-out test is an important micromechanical test used to evaluate the fibre-matrix interface of polymer matrix composites primarily under shear stress.
Carol Winnifred Rodricks, Gerhard Kalinka   +1 more
doaj   +1 more source

The Pull Test: A Dynamic Test to Confirm Hip Microinstability

Arthroscopy, Sports Medicine, and Rehabilitation, 2019
Purpose: To define a distraction distance (pull length) cut-off that would differentiate those patients with hip microinstability and those without the disorder, called the Pull-Out Test.
Kostas J. Economopoulos, M.D., Christopher Y. Kweon, M.D., Albert O. Gee, M.D., Suzanne T. Morris, N.P.-C., Jeffrey D. Hassebrock, M.D., Anikar Chhabra, M.D.   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source