Results 91 to 100 of about 950,441 (251)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Automated Cardiff Model Complexity Identification and Parameters Extraction From Measured Tailored A-Pull Data

IEEE Journal of Microwaves
This paper presents a novel experimental technique for automatically identifying the complexity and coefficients of a Cardiff behavioral model of a microwave transistor using a conventional, narrowband active load-pull system.
Azam Al-Rawachy, Alexander Baddeley, Abdalla Eblabla, Dragan Gecan, Aamir Sheikh, Aleksander Bogusz, Roberto Quaglia, Paul J. Tasker   +7 more
doaj   +1 more source

Experimental Study on Friction Characteristics of Geogrid-Loess Interface [PDF]

长江科学院院报
[Objective] Geogrids are widely applied in high loess slopes engineering due to their advantages of strong overall durability, high tensile strength, and corrosion resistance.
CAI Xiao-guang, YUAN Chao, LI Si-han, XU Hong-lu, WANG Xue-peng
doaj   +1 more source

Image processing for the extraction of nutritional information from food labels [PDF]

, 2015
Current techniques for tracking nutritional data require undesirable amounts of either time or man-power. People must choose between tediously recording and updating dietary information or depending on unreliable crowd-sourced or costly maintained ...
Matsunaga, Nate, Sullivan, Rick
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Pembangkit Listrik Tenaga Lat Pull Down (Alat Fitnes) Segabai Sumber Energi Alternatif [PDF]

, 2014
Penggunaan energi listrik semakin meningkat, sedangkan pasokan energi listrik di tuntut untuk memenuhi kebutuhan energi listrik tersebut. Pembuatan pembangkit listrik tenaga Lat pull down merupakan salah satu alat yang bisa dimanfaatkan sebagai energi ...
, Hasyim Asy’ari, ST.MT, , Ir. Jatmiko, M.T., Septiawan, Fendi   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Railway crossing with adjustable pulling force as function of loading [PDF]

Transport Problems, 2009
In this paper presents the concept of controlling the pulling force as a function of loading of railway crossing that was modelled as a discrete-continuous system.
Jan TARGOSZ, Tomasz BURATOWSKI
doaj