Results 71 to 80 of about 173,975 (266)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Experimental Study on Friction Characteristics of Geogrid-Loess Interface [PDF]
长江科学院院报[Objective] Geogrids are widely applied in high loess slopes engineering due to their advantages of strong overall durability, high tensile strength, and corrosion resistance.
CAI Xiao-guang, YUAN Chao, LI Si-han, XU Hong-lu, WANG Xue-peng
doaj +1 more source
Power Pull: an unconditionally stable active Load-Pull measurement system
, 1998 For today's communication circuits optimum operational conditions for almost every Tx power amplifier is one of the most important parameters. Only this will offer maximum power added efficiency and output power. For the experimental determination of these conditions load-pull measurements are the best solution. To compensate losses of the setup for on-
Koether, D., Sporkmann, Th.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Towards Keyword-based Pull Recommendation Systems
Proceedings of the 18th International Conference on Enterprise Information Systems, 2016 Due to the high availability of data, users are frequently overloaded with a huge amount of alternatives when they need to choose a particular item. This has motivated an increased interest in research on recommendation systems, which filter the options and provide users with suggestions about specific elements (e.g., movies, restaurants ...
María del Carmen Rodríguez-Hernández +3 more
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Deep Learning-Based Intelligent Detection Device for Insulation Pull Rod Defects
EnergiesThis paper proposes a deep learning-based intelligent detection device for insulation pull rod defects, addressing the issues of low detection accuracy, poor timeliness of intelligent analysis, and the difficulty in preserving detection results. Firstly,
Hua Yu +7 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Chemical Mediation of Oviposition by Anopheles Mosquitoes: a Push-Pull System Driven by Volatiles Associated with Larval Stages. [PDF]
J Chem Ecol, 2020 Schoelitsz B +7 more
europepmc +1 more source