Results 11 to 20 of about 20,429 (117)

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A. Roberts, Thomas Tängdén, Athena Zuppa, Marc H. Scheetz   +16 more
wiley   +1 more source

Using random forest machine learning on data from a large, representative cohort of the general population improves clinical spirometry references

The Clinical Respiratory Journal, Volume 17, Issue 8, Page 819-828, August 2023., 2023
Abstract Introduction Spirometry is associated with several diagnostic difficulties, and as a result, misdiagnosis of chronic obstructive pulmonary disease (COPD) occurs. This study aims to investigate how random forest (RF) can be used to improve the existing clinical FVC and FEV1 reference values in a large and representative cohort of the general ...
Kris Kristensen, Pernille H. Olesen, Anna K. Roerbaek, Louise Nielsen, Helle K. Hansen, Simon L. Cichosz, Morten H. Jensen, Ole Hejlesen   +7 more
wiley   +1 more source

Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 14, Issue 2, Page 1060-1074, April 2023., 2023
Abstract Background Sarcopenia is defined by the progressive and generalized loss of muscle mass and function associated with aging. We have previously proposed that aging‐related hyperphosphataemia is linked with the appearance of sarcopenia signs. Because there are not effective treatments to prevent sarcopenia, except for resistance exercise, we ...
Elena Alcalde‐Estévez, Patricia Sosa, Ana Asenjo‐Bueno, Patricia Plaza, Pedro L. Valenzuela, Manuel Naves‐Díaz, Gemma Olmos, Susana López‐Ongil, María P. Ruiz‐Torres   +8 more
wiley   +1 more source

Metallodrugs: an approach against invasion and metastasis in cancer treatment

FEBS Open Bio, Volume 12, Issue 5, Page 880-899, May 2022., 2022
In this review, we examine the use of metallodrugs for cancer treatment, focussing on the advances in this type of therapy and the importance of these compounds, with emphasis on Pt, Ru, Au, Zn, and Cu as antimetastatic agents. In addition, we discuss the different mechanisms of action by which metallodrugs exert their therapeutic effects.
Mauricio M. González‐Ballesteros, Carmen Mejía, Lena Ruiz‐Azuara   +2 more
wiley   +1 more source

Fetal movements: the origin of human behaviour

Developmental Medicine &Child Neurology, Volume 63, Issue 10, Page 1142-1148, October 2021., 2021
The study of the onset and ontogeny of human behaviour has made it clear that a multitude of fetal movement patterns are spontaneously generated, and that there is a close association between activity and the development of peripheral and central structures.
Christa Einspieler, Daniela Prayer, Peter B Marschik   +2 more
wiley   +1 more source

Advancing science and education through a novel collaboration platform between the University of Michigan and Peking University Health Science Center

FASEB BioAdvances, Volume 3, Issue 6, Page 428-438, June 2021., 2021
Abstract Research in China has been advancing over the past decade with increasing investments from government and private entities. Collaboration with Chinese investigators and those in the United States has also increased as reflected in the growth of scientific papers with Chinese authors. Collaborations are more commonly based on faculty‐to‐faculty
Joseph C. Kolars, Qimin Zhan
wiley   +1 more source

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population‐based study

BJS Open, Volume 4, Issue 4, Page 685-692, August 2020., 2020
In a study of the incidence and management of metastatic colorectal cancer in a population‐based cohort, 17·7 per cent of 1671 patients with colorectal cancer had synchronous metastases, and 19·6 per cent of 1302 patients who had resection of stage I–III tumours developed metachronous metastases. In the whole population, the proportion of patients with
V. Väyrynen, E.‐V. Wirta, T. Seppälä, E. Sihvo, J.‐P. Mecklin, K. Vasala, I. Kellokumpu   +6 more
wiley   +1 more source

Liver resection with thrombectomy for patients with hepatocellular carcinoma and tumour thrombus in the inferior vena cava or right atrium

BJS Open, Volume 4, Issue 2, Page 241-251, April 2020., 2020
Hepatocellular carcinoma with tumour thrombus in the inferior vena cava or right atrium is an advanced disease state with a poor prognosis. This retrospective study examined the survival benefits of surgical resection for patients with this rare condition.
S. Matsukuma, H. Eguchi, H. Wada, T. Noda, Y. Shindo, Y. Tokumitsu, H. Matsui, H. Takahashi, S. Kobayashi, H. Nagano   +9 more
wiley   +1 more source

Influence of socioeconomic status on immediate breast reconstruction rate, patient information and involvement in surgical decision‐making

BJS Open, Volume 4, Issue 2, Page 232-240, April 2020., 2020
Socioeconomic factors independently influence immediate breast reconstruction rates in Sweden. Patient‐reported information and involvement in the surgical decision‐making process remain independent predictors of the likelihood of undergoing immediate breast reconstruction.
A. Frisell, J. Lagergren, M. Halle, J. de Boniface   +3 more
wiley   +1 more source

The social return on investment of a new approach to heart failure in the Spanish National Health System

ESC Heart Failure, Volume 7, Issue 1, Page 131-138, February 2020., 2020
Abstract Aims We aim to agree on a set of proposals to improve the current management of heart failure (HF) within the Spanish National Health System (SNHS) and apply the social return on investment (SROI) method to measure the social impact that these proposals would generate.
María Merino, Margarita Jiménez, Nicolás Manito, Emilio Casariego, Yoana Ivanova, Almudena González‐Domínguez, Maite San Saturnino, Álvaro Hidalgo‐Vega, Carles Blanch   +8 more
wiley   +1 more source