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Endothelial MLKL Inhibition Reduces Hyperoxia‐Induced Bronchopulmonary Dysplasia in Neonatal Mice

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Bronchopulmonary dysplasia (BPD) remains a severe complication in premature infants requiring prolonged oxygen therapy, with vascular endothelial dysfunction recognised as a critical contributor to disease progression. Mixed lineage kinase domain‐like protein (MLKL)‐mediated necroptosis, an essential form of regulated cell death implicated in ...
Junjie Ning, Junchao Deng, Yating Sang, Lina Qiao +3 more
wiley +1 more source

Alveolar deadspace and intrapulmonary shunt in healthy individuals and in individuals who have recovered from COVID‐19 infection

Experimental Physiology, Volume 111, Issue 2, Page 556-567, 1 February 2026.
Abstract Following acute COVID‐19 infection, unvaccinated patients have been reported to exhibit elevated alveolar deadspace (̇VD,alv/̇VT) and intrapulmonary shunt (̇Qs/̇QT) fractions. However, as there is uncertainty surrounding the upper limits of normal for ̇VD,alv/̇VT and ̇Qs/̇QT, we sought to replicate the findings from a separate, previously ...
Dominic Sandhu +7 more
wiley +1 more source

A window on the lung: Molecular imaging as a tool to dissect pathophysiologic mechanisms of acute lung disease [PDF]

, 2019
Musch, Guido
core +1 more source

Pulmonary Administration of GW0742, a High-Affinity Peroxisome Proliferator-Activated Receptor Agonist, Repairs Collapsed Alveoli in an Elastase-Induced Mouse Model of Emphysema