Results 91 to 100 of about 646,706 (317)

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic   +74 more
wiley   +1 more source

High level of initial Aspergillus fumigatus-specific IgE links increased risk of exacerbation in allergic bronchopulmonary aspergillosis patients

Respiratory Research
Background Elevated Aspergillus fumigatus (A. fumigatus)-specific Immunoglobulin E (IgE) is recognized as an essential diagnostic criterion for allergic bronchopulmonary aspergillosis (ABPA). However, it remains unknown whether initial A.
Hao Qian, Jia-Yan Xu, Rui Fan, Jing Shi, Hai-Wen Lu, Ling Ye, Jia-Wei Yang, Rui Jiang, Li-Sha Zhang, Yi-Fan Wu, Mei-Ling Jin, Jin-Fu Xu   +11 more
doaj   +1 more source

Xpert MTB/RIF assay for the differential diagnosis between sarcoidosis and tuberculosis intrathoracic lymphadenopathy

BMC Infectious Diseases, 2023
Background The aim of this study was to evaluate the role of Xpert MTB/RIF assay in the detection of Mycobacterium tuberculosis for differentiating tuberculosis intrathoracic lymphadenopathy from sarcoidosis intrathoracic lymphadenopathy.
Xian He, Yuan Zhang, Ying Zhou, Li Li, Qiuhong Li   +4 more
doaj   +1 more source

Ergonomics of bronchoscopy: good advice or a pain in the neck?

European Respiratory Review, 2023
Interventional pulmonologists require a unique set of skills including precise motor abilities and physical endurance, but surprisingly the application of ergonomic principles in the field of bronchoscopy remains limited.
Prince Ntiamoah, Michael Machuzak, Thomas R. Gildea, Atul C. Mehta   +3 more
doaj   +1 more source

A Multi‐Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales. Methods Incident probable or definite neurosarcoidosis myelitis in adults was retrospectively identified from 13 academic medical centers.
Giovanna S. Manzano, Denis Balaban, Yihan Zhang, Brian Healy, Bart K. Chwalisz, Michael Levy, Nagagopal Venna, Barney J. Stern, Carlos A. Pardo, Paula Barreras, Nicole Bou Rjeily, Eoin P. Flanagan, Vyanka Redenbaugh, Allen J. Aksamit Jr., Spencer Hutto, Max Herman, Sally El Sammak, Elsa C. Rodriguez, Laura Snider, Hannah Rains, Mayra Montalvo, Torge Rempe, Sergi Martinez Ramirez, Lucas Horta, Stacey Clardy, Jennifer Lord, Tracey A. Cho, Lama Abdel Wahed, Joseph R. Berger, Rohini D. Samudralwar, Noellie Rivera Torres, David B. Clifford, Steven Richard Dunham, Masoud Majed, Aram Zabeti, Samuel Marcucci, Yang Mao‐Draayer, Jon Doty, Paunel B. Agyei, Shamik Bhattacharyya   +39 more
wiley   +1 more source

Extracellular matrix remodelling in COPD

European Respiratory Review, 2020
The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it offers a low resistant pathway that allows the exchange of gases, provides compressive strength and elasticity that supports the fragile alveolar–capillary ...
Meropi Karakioulaki, Eleni Papakonstantinou, Daiana Stolz   +2 more
doaj   +1 more source

Breathlessness and exercise with virtual reality system in long-post-coronavirus disease 2019 patients

Frontiers in Public Health, 2023
Long-post-coronavirus disease-2019 (COVID-19) patients tend to claim residual symptomatology from various systems, most importantly the respiratory and central nervous systems. Breathlessness and brain fog are the main complaints.
Vasileios T. Stavrou, George D. Vavougios, George D. Vavougios, Periklis Kalogiannis, Konstantinos Tachoulas, Evlalia Touloudi, Kyriaki Astara, Kyriaki Astara, Dimitrios S. Mysiris, Glykeria Tsirimona, Eirini Papayianni, Stylianos Boutlas, Mary Hassandra, Zoe Daniil, Zoe Daniil, Yannis Theodorakis, Konstantinos I. Gourgoulianis, Konstantinos I. Gourgoulianis   +17 more
doaj   +1 more source

Analysis of the Characteristics of Patients Presenting with Exacerbation of Asthma to Emergency Care Units [PDF]

, 2015
Background:Fatal asthma remains a serious problem, and patient self-management of asthma is important to prevent exacerbation. To reduce the asthma mortality rate, we analyzed the characteristics of patients who visited an emergency care unit with ...
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Hideyuki Satoh, Kentaro Nakano, Kumiya Sugiyama, Naruo Yoshida, Ryosuke Souma, Shingo Tokita, Takeshi Fukuda, Tomoshige Wakayama, Yasutsugu Fukushima   +17 more
core   +1 more source

Early Multi-organ Point-of-Care Ultrasound Evaluation of Respiratory Distress During SARS-CoV-2 Outbreak: Case Report [PDF]

, 2020
Introduction: Coronavirus disease 2019 (COVID-19) is caused by the virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).  Several case series from Italy and China have highlighted the lung ultrasound findings of this disease ...
Becherer-Bailey, Graham, Farrow II, Robert, Mantuani, Daniel, Nagdev, Arun   +3 more
core  

Cancer Risk in Patients With Systemic Sclerosis: A Nationwide Cohort Study in South Korea 2004 to 2021

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site‐specific cancer risks in patients with SSc compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore ...
Jihyun Na, Su Jin Choi, Sojeong Park, Minae Park, Doo‐Ho Lim   +4 more
wiley   +1 more source