Results 71 to 80 of about 500,767 (302)
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Nature CommunicationsThe management of bronchiectasis-asthma overlap (BAO) is an important clinical issue to be addressed. Little is known regarding the endotype of BAO. Here we recruit patients with a primary diagnosis of bronchiectasis and co-existing asthma. The levels of
Yu-Wei Zhang +15 more
doaj +1 more source
Overlap Syndrome in Respiratory Medicine: Asthma and Chronic Obstructive Pulmonary Disease
Journal of Cardio-Thoracic Medicine, 2014 Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. However, the distinction between the two obstructive diseases is not always clear.
Corlateanu, Alexandru +3 more
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
BMC Pulmonary MedicineBackground The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood. Methods This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018.
Yu-Hua Wen +7 more
doaj +1 more source
Respiratory Medicine in general practice: what is the role of the pulmonary specialist?
Monaldi Archives for Chest Disease, 2005 -
openaire +3 more sources
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
End of an ERA: lessons from negative clinical trials in idiopathic pulmonary fibrosis
, 2011 Comment on "BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis." [American Journal of Respiratory and Critical Care Medicine ...
Kaminski, Naftali +7 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos +2 more
wiley +1 more source
Extracellular matrix remodelling in COPD
European Respiratory Review, 2020 The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it offers a low resistant pathway that allows the exchange of gases, provides compressive strength and elasticity that supports the fragile alveolar–capillary ...
Meropi Karakioulaki +2 more
doaj +1 more source