Results 111 to 120 of about 646,706 (317)

Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: A randomized non-inferiority study [PDF]

, 2018
Background: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patients with chronic obstructive ...
Birk, Ruby, Brealey, Noushin, Bremner, Peter R, Ismaila, Afisi S, Lipson, David A, Zhu, Chang-Qing   +5 more
core   +2 more sources

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Obstructive sleep apnea syndrome and perioperative complications: a systematic review of the literature. [PDF]

, 2012
Obstructive sleep apnea syndrome (OSAS) is a common sleep related breathing disorder. Its prevalence is estimated to be between 2% and 25% in the general population.
Doghramji, MD, Karl, Grewal, MD, Ritu G., Vasu, MD, MS, Tajender S.   +2 more
core   +2 more sources

An Optoelectrically Switched, Dual‐Mode Neuromorphic Sensor for Transient and Accumulative Gas Detection

Advanced Functional Materials, EarlyView.
A transistor‐type carbon nanotube gas sensor with dual‐mode detection capability has been proposed. By simply adjusting the gate voltage and UV illumination, this sensor enables both real‐time detection and accumulation‐based sensing of toxic gases within a single device, providing a compact and adaptable platform for environmental monitoring ...
Jaewon Shin, Young‐Woo Jang, Seung‐Han Kang, Jeong‐Wan Jo, Jong Wook Shin, Yong‐Hoon Kim, Sung Kyu Park, Sung Woon Cho   +7 more
wiley   +1 more source

The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Mediators of Inflammation, 2019
Background. Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF. Objectives.
Dong Weng, Xian-Qiu Chen, Hui Qiu, Yuan Zhang, Qiu-Hong Li, Meng-Meng Zhao, Qin Wu, Tao Chen, Yang Hu, Liu-Sheng Wang, Ya-Ru Wei, Yu-Kui Du, Shan-Shan Chen, Ying Zhou, Fen Zhang, Li Shen, Yi-Liang Su, Martin Kolb, Hui-Ping Li   +18 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

The role of endothelin-1 in pulmonary arterial hypertension. [PDF]

, 2014
Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher. [PDF]

, 2016
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detrimental cardiovascular or respiratory effects.
Amodeo, Guido, Bernardini, Achille, Berruto, Francesco, Filippini, Matteo, Fiorillo, Marialinda, Grazioli, Michele, Lucangelo, U., Marsilia, Paolo F., Minelli, Cosetta, Natalini, Giuseppe, Pennestr\uec, Vincenzo, Peratoner, Alberto, Rosano, Antonio, Testa, Marco, Tinnirello, Andrea, Tuzzo, Daniele, Ventilab, Group   +16 more
core   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source