Results 131 to 140 of about 468,103 (315)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

COPD Patients with a High Exacerbation Risk: Baseline Data Analysis of a National Chinese Prospective Multi-Center Study of Quality Improvement Project

International Journal of COPD
Kai Yang,1,* Dandan Chen,1,* Yan Wang,1,* Fengyan Wang,2 Lingwei Wang,1 Jing Wang,3 Tingfeng Yu,4 Huina Hou,5 Wei Liu,6 Peirong Huang,7 Hongying Yang,8 Rongchang Chen1,2 1Department of Pulmonary and Critical Care Medicine ...
Yang K, Chen D, Wang Y, Wang F, Wang L, Wang J, Yu T, Hou H, Liu W, Huang P, Yang H, Chen R   +11 more
doaj  

Clinical and radiological features associated with rupture of pulmonary artery pseudoaneurysm: a retrospective study

BMC Pulmonary Medicine
Background Hemoptysis resulting from rupture of the pulmonary artery pseudoaneurysm (PAP) is massive and fatal, while factor contributing to the rupture of pseudoaneurysm remains elusive.
Min Liu, Jixiang Liu, Wei Yu, Xiaoyan Gao, Shi Chen, Wei Qin, Ziyang Zhu, Chenghong Li, Fajiu Li, Zhenguo Zhai   +9 more
doaj   +1 more source

Outcome prediction for patients with obstructive lung disease considered for admission to critical care units in England, Wales and Northern Ireland [PDF]

Objective. To develop an outcome prediction score for patients with obstructive lung disease considered for admission to critical care. Design. Prospective cohort study using multivariate logistic regression for model building
Wildman, Martin James
core   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

A case report of empyema caused by Enterococcus gallinarum

BMC Infectious Diseases
Background Enterococcus gallinarum is an infrequently intestinal symbiotic pathogen associated with nosocomial infection in immunocompromised individuals.
Min Liu, Jixiang Liu, Juanjuan Wu, Shuang Liu, Lu Sun, Fajiu Li, Chenghong Li   +6 more
doaj   +1 more source

Longitudinal assessment of cystic fibrosis pulmonary diseaseusing clinical, biochemical and emerging microbiological techniques

, 2010
Cystic Fibrosis (CF) causes chronic lower respiratory tract infection leading to morbidity and mortality. CF Pulmonary Exacerbations (CFPEs) cause accentuated symptoms and increase mortality.
Daniels, Thomas William Vaisey
core  

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

AI-Assisted Interpretation of Pulmonary Function Tests: Enhancing Diagnostic Precision in Respiratory Medicine

Journal of Pharmacy and Bioallied Sciences
Background: Interpreting pulmonary function tests (PFTs) accurately is essential for diagnosing and monitoring respiratory disorders. However, manual interpretation is subject to interobserver variability. Artificial intelligence (AI) offers a promising tool to enhance diagnostic consistency and accuracy.
Singh, Ajay, Sahu, Manoj, Padarya, Surendra K., Saad, Talha, Mishra, Satyendra, Singh, Mayank P.   +5 more
openaire   +3 more sources