Results 131 to 140 of about 679,434 (313)

Associations between respiratory signs and abnormalities reported in thoracic CT scans of cats [PDF]

, 2016
Aarsvold, Aspinall, Cohn, Corcoran, Dye, Eng, Foster, Gadbois, Hansell, Henao-Guerrero, Henninger, Johnson, Laflamme, Macdonald, Mexas, Moise, Moynihan, Nemanic, Oliveira, Padrid, Reinero, Robinson, Sauve, Sigrist, Simone, Staffieri, Swift, Trzil, Wood   +28 more
core   +2 more sources

Initial self-reported data on sleep and burnout in pulmonary, critical care and sleep medicine: an initiative from the Assembly on Sleep and Respiratory Neurobiology of the American Thoracic Society

Respiratory Research
Health worker burnout has reached crisis proportions, threatening workforce sustainability. Limited data exist on the burden of burnout in pulmonary, critical care and sleep medicine (PCCSM), a high-demand and strained specialty.At the Assembly of Sleep and Respiratory Neurobiology of the American Thoracic Society, we aimed to gather exploratory data ...
Sushmita Pamidi, Reena Mehra, Indira Gurubhagavatula, Mihaela Teodorescu   +3 more
openaire   +3 more sources

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Dynamic liver dysfunction predicts poor survival in patients with EGFR-mutant non-small cell lung cancer and liver metastases treated with EGFR tyrosine kinase inhibitors

BMC Cancer
Background Liver metastasis is an adverse prognostic factor in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC).
Wen Zhang, Xuemei Wu, Xiaorong Sun, Jian Wen, Xiaoli He, Mingzhou Zhang, Guansong Wang, Zhi Xu   +7 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Clinical and radiological features associated with rupture of pulmonary artery pseudoaneurysm: a retrospective study

BMC Pulmonary Medicine
Background Hemoptysis resulting from rupture of the pulmonary artery pseudoaneurysm (PAP) is massive and fatal, while factor contributing to the rupture of pseudoaneurysm remains elusive.
Min Liu, Jixiang Liu, Wei Yu, Xiaoyan Gao, Shi Chen, Wei Qin, Ziyang Zhu, Chenghong Li, Fajiu Li, Zhenguo Zhai   +9 more
doaj   +1 more source

A study of general practice consultations at Mosta Health Centre, Malta [PDF]

, 2013
Primary care is the first contact for patients with health related problems. In Malta, primary health is provided by both private and state sectors. The state services are free-of-charge and provide a 24 hrs walk-in GP service at health centres as ...
Cuschieri, Sarah, Sammut, Mario R.
core  

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source