Results 131 to 140 of about 194,414 (305)

Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model

, 2015
Item does not contain fulltextIncreased serotonin serum levels have been proposed to play a key role in pulmonary arterial hypertension (PAH) by regulating vessel tone and vascular smooth muscle cell proliferation.
Voelkel, N.F., Middelman, Anthonieke, de Jong, Helma, Bogaard, Harm Jan, Jong, H. de, Kroeze, Yvet, de Jong, H., Korte, C.L. de, Man, F.S. de, de Man, Frances S., Middelman, A., de Raaf, Michiel Alexander, de Korte, Chris, de Korte, C., Raaf, M.A. de, Homberg, J., Bogaard, H.J., de Man, F.S., Voelkel, Norbert F., Vonk-Noordegraaf, Anton, de Raaf, M.A., Homberg, Judith, Kroeze, Y.L., Vonk-Noordegraaf, A., Kroeze, Y.   +24 more
core   +1 more source

Single Centre Experience With the Balloon‐Expandable Myval Transcatheter Aortic Valve System in Patients With Bicuspid Anatomy: 1 Year Follow‐Up

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter aortic valve implantation (TAVI) in bicuspid aortic valve (BAV) anatomy remains challenging due to anatomical complexity and limited trial data. New‐generation balloon‐expandable valves, such as Myval, require further evaluation in this subgroup.
Balázs Magyari, Bálint Kittka, Ilona Goják, Gábor Kasza, Kristóf Schönfeld, László Botond Szapáry, Mihály Simon, Rudolf Kiss, Andrea Bertalan, Edit Várady, István Szokodi, Iván Horváth   +11 more
wiley   +1 more source

Pulmonary hypertension

, 2015
Pulmonary hypertension (PH) is a haemodynamic condition that leads to a progressive increase in pulmonary vascular resistance and mean pulmonary artery pressure.
Vonk Noordegraaf, Anton, van der Bruggen, Cathelijne E. E., Spruijt, Onno A., Meijboom, Lilian J.   +3 more
core   +1 more source

Nine‐Year Follow‐Up After M‐TEER for Secondary Mitral Regurgitation in a Patient With Cardiogenic Shock

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter edge‐to‐edge repair (TEER) has become an established therapeutic option for patients with severe secondary mitral regurgitation (SMR). While randomized trials and registry data have reported outcomes up to 5 years, longer follow‐up data remain scarce.
Tobias Reithmayer, Thomas J. Stocker, Ludwig T. Weckbach, Julia Novotny, Philipp M. Doldi, Hannah Kempton, Steffen Massberg, Michael Näbauer, Jörg Hausleiter, Lukas Stolz   +9 more
wiley   +1 more source

Arterial pulmonary hypertension in noncardiac intensive care unit

, 2008
Mykola V Tsapenko1,5, Arseniy V Tsapenko2, Thomas BO Comfere3,5, Girish K Mour1,5, Sunil V Mankad4, Ognjen Gajic1,51Division of Pulmonary and Critical Care Medicine; 3Division of Critical Care Medicine; 4Division of Cardiovascular Diseases, Mayo ...
Thomas BO Comfere, Ognjen Gajic, Girish K Mour, Arseniy V Tsapenko, Sunil V Mankad, Mykola V Tsapenko   +5 more
core  

Noninvasive identification of left-sided heart failure in a population suspected of pulmonary arterial hypertension

, 2015
Exclusion of pulmonary hypertension secondary to left-sided heart disease (left heart failure (LHF)) is pivotal in the diagnosis of pulmonary arterial hypertension (PAH). In case of doubt, invasive measurements are recommended.
Heymans, M.W., Vonk-Noordegraaf, A., Bogaard, H.J., Jacobs, W., Konings, T.C., Boonstra, A., van Rossum, A.C.   +6 more
core   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

The Swiss registry for pulmonary arterial hypertension: the paediatric experience.

, 2007
Pulmonary arterial hypertension is a rare disease with a poor prognosis. Epidemiological data are scarce, particularly in the paediatric population. A registry was recently developed in order to collect epidemiological data on patients with pulmonary ...
Tolsa, J.F., Fasnacht, M.S., Beghetti, M.   +2 more
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS

Hepatology, EarlyView., 2022
The river diagram demonstrates that after transjugular intrahepatic portosystemic shunt insertion (TIPS) the majority of patients without ascites and 50% of the patients with ascites detectable at ultrasound, show the best response in the long term follow‐up.
Alexander Queck, Louise Schwierz, Wenyi Gu, Philip G. Ferstl, Christian Jansen, Frank E. Uschner, Michael Praktiknjo, Johannes Chang, Maximilian J. Brol, Filippo Schepis, Manuela Merli, Christian P. Strassburg, Jennifer Lehmann, Carsten Meyer, Jonel Trebicka   +14 more
wiley   +1 more source