Results 171 to 180 of about 423,899 (348)

Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension

BMC Cardiovascular Disorders, 2017
Background Despite the increased risk for pulmonary hypertension in children with Down syndrome, the response to treatment with targeted therapies for pulmonary hypertension in these patients is not well characterized.
Maurice Beghetti, Andrzej Rudzinski, Min Zhang   +2 more
doaj   +1 more source

Pathophysiologic correlates of exercise intolerance in adults with pulmonary hypertension and congenital heart disease [PDF]

, 2009
Imperial Users ...
Diller , Gerhard-Paul, Diller , Gerhard-Paul   +1 more
core  

Luspatercept for Transfusion‐Dependent Beta‐Thalassemia: Real‐World Experience in a Large Cohort of Patients From Italy

American Journal of Hematology, EarlyView.
Raffaella Origa, Barbara Gianesin, Antonietta Zappu, Anna Rita Denotti, Mary Ann Di Giorgio, Roberta Sciortino, Irene Motta, Daniele Lello Panzieri, Rosamaria Rosso, Anna Bulla, Martina Culcasi, Anna Maria Pasanisi, Lucia De Franceschi, Rosario Di Maggio, Valeria Maria Pinto, Paola Maria Grazia Sanna, Paolo Ricchi, Giovan Battista Ruffo, Francesca Schieppati, Domenico Roberti, Giovanni Battista Ferrero, Elisa De Michele, Francesco Arcioni, Ilaria Fotzi, Sarah Marktel, Antonella Poloni, Giulia Soverini, Epifania Rita Testa, Giusy Cabiddu, Carmelo Fortugno, Antonia Gigante, Francesca Polese, Davide Rapezzi, Antonella Sau, Gian Luca Forni, Maria Domenica Cappellini, Filomena Longo   +36 more
wiley   +1 more source

Activin A–Activated ALK4 Induces Pathogenic Th17‐Involved Endothelial–Mesenchymal Transition in Systemic Lupus Erythematosus–Associated Pulmonary Arterial Hypertension

Arthritis &Rheumatology, EarlyView.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE has not been clarified.
Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J. Bogaard, Lie Wang, Mengtao Li, Jun Yang   +9 more
wiley   +1 more source

Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation.
Thaís C. F. Menezes, Michael H. Lee, Dara C. Fonseca Balladares, Kevin Nolan, Sankalp Sharma, Rahul Kumar, Eloara V. M. Ferreira, Brian B. Graham, Rudolf K. F. Oliveira   +8 more
doaj   +1 more source

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

Do we need controlled clinical trials in pulmonary arterial hypertension? [PDF]

, 2001
Nazzareno Galiè
openalex   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Pulmonary Circulation, 2019
In order to intervene appropriately and develop disease-modifying therapeutics for pulmonary arterial hypertension, it is crucial to understand the mechanisms of disease pathogenesis and progression.
Edda Spiekerkoetter, Elena A. Goncharova, Christophe Guignabert, Kurt Stenmark, Grazyna Kwapiszewska, Marlene Rabinovitch, Norbert Voelkel, Harm J. Bogaard, Brian Graham, Soni S. Pullamsetti, Wolfgang M. Kuebler   +10 more
doaj   +1 more source

Genetic aspect of pulmonary arterial hypertension [PDF]

, 2001
Jane H. Morse, Zemin Deng, James A. Knowles   +2 more
openalex   +1 more source