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Pulmonary Arterial Hypertension
Current Problems in Cardiology, 2011Pulmonary hypertension is a complex and multidisciplinary disorder. The classification of pulmonary hypertension includes 5 groups. Pulmonary arterial hypertension is a rare disorder that can be idiopathic or heritable in nature, or associated with other conditions, such as scleroderma or congenital heart disease.
Vallerie V, McLaughlin +2 more
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Pulmonary Arterial Hypertension
Heart Failure Clinics, 2018This article provides an overview of pulmonary arterial hypertension (PAH), beginning with the initial pathologic recognition of pulmonary hypertension more than 100 years ago and progressing to the current diagnostic categorization of PAH. It reviews the epidemiology, pathophysiology, genetics, and modern treatment of PAH.
Mark W, Dodson +2 more
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Pulmonary Arterial Hypertension
Current Vascular Pharmacology, 2010The last 10 years have seen significant advances in the understanding of the pathophysiology and treatment of pulmonary arterial hypertension (PAH). This has included new insights into the genetics, cell-signalling pathways and pathological changes seen in the small pulmonary arteries as well as the introduction of new treatments which have improved ...
Christiana, Burt +2 more
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Management of Pulmonary Arterial Hypertension
Seminars in Respiratory and Critical Care Medicine, 2023AbstractPulmonary arterial hypertension (PAH) is a rare pulmonary vascular disease characterized by progressive pulmonary arterial remodeling, increased pulmonary vascular resistance, right ventricular dysfunction, and reduced survival. Effective therapies have been developed that target three pathobiologic pathways in PAH: nitric oxide, endothelin-1 ...
Jason, Weatherald +3 more
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Pulmonary arterial hypertension in women
Revue des Maladies Respiratoires, 2010Pulmonary arterial hypertension (PAH) is a rare condition characterized by sustained elevation in pulmonary arterial resistance leading to right heart failure.PAH afflicts predominantly women. Echocardiography is the initial investigation of choice for non-invasive detection of PAH but right-heart catheterization is necessary to confirm the diagnosis ...
O, Sanchez +5 more
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Echocardiography in Pulmonary Arterial Hypertension
Current Cardiology Reports, 2019Pulmonary arterial hypertension (PAH) is a devastating disease which can result in right heart (RH) failure and death. Herein, we discuss the current clinical applications of echocardiography in PAH.Advanced echocardiographic techniques (strain, strain rate, 2D-speckle tracking strain, and three-dimensional echocardiography) may reveal in the near ...
Ferrara F. +9 more
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Inflammation in Pulmonary Arterial Hypertension
2021Pulmonary artery hypertension (PAH) is a devastating cardiopulmonary disease characterized by vascular remodeling and obliteration of the precapillary pulmonary arterioles. Alterations in the structure and function of pulmonary vessels result in the resistance of blood flow and can progress to right-sided heart failure, causing significant morbidity ...
Timothy, Klouda, Ke, Yuan
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Epoprostenol in pulmonary arterial hypertension
Expert Opinion on Drug Metabolism & Toxicology, 2008Pulmonary arterial hypertension (PAH) is a devastating disease leading to right heart failure and death in a relatively young patient population. In recent years novel PAH specific therapies have become available.To determine the place of epoprostenol in current PAH treatment strategies.An extensive Medline search was performed to evaluate the use of ...
Jacobs, W., Vonk Noordegraaf, A.
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Sildenafil for Pulmonary Arterial Hypertension
American Journal of Therapeutics, 2019Pulmonary hypertension is a life-threatening illness with debilitating physical and emotional consequences. The progression of this devastating disease is characterized by a continuous increase in pulmonary vascular resistance, which results in elevated pulmonary artery pressure and leads to right heart failure.
Bhogal, Sukhdeep +5 more
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Ambrisentan for Pulmonary Arterial Hypertension
Future Cardiology, 2005Endothelin receptor antagonists (ERAs) are an important class of agents used for the treatment of pulmonary arterial hypertension (PAH). Ambrisentan is an oral, once-daily, endothelin type-A receptor (ETA)-selective, propanoic acid class ERA under clinical investigation for the treatment of PAH.
Lewis J, Rubin +2 more
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