Results 141 to 150 of about 354,714 (311)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Machine Learning‐Based Estimation of Experimental Artifacts and Image Quality in Fluorescence Microscopy

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of image quality metrics in combination with machine learning enables automatic image quality assessment for fluorescence microscopy images. The method can be integrated into the experimental pipeline for optical microscopy and utilized to classify artifacts in experimental images and to build quality rankings with a reference‐free approach ...
Elena Corbetta, Thomas Bocklitz
wiley   +1 more source

Role of Magnetic Resonance Angiography in the Diagnosis of Major Aortopulmonary Collateral Arteries and Partial Anomalous Pulmonary Venous Drainage [PDF]

, 2004
Sanjay Prasad, N Soukias, Thomasina Hornung, M. GABRIEL KHAN, Dudley J. Pennell, Michael Α. Gatzoulis, Raad Mohiaddin   +6 more
openalex   +1 more source

Autonomous Recognition of Retained Secretions in Central‐Airway Based on Deep Learning for Adult Patients Receiving Invasive Mechanical Ventilation

Advanced Intelligent Systems, EarlyView.
This work presents a deep learning model to autonomously recognize and classify the secretion retention into three levels for patients receiving invasive mechanical ventilation, achieving 89.08% accuracy. This model can be implemented to ventilators by edge computing, whose feasibility is approved.
Shuai Wang, Zhuoran Xiao, Meng Wang, Jianchao Li, Chunjing Tao, Jiangzhen Guo, Yubo Fan   +6 more
wiley   +1 more source

Does the degree of preoperative mitral regurgitation predict survival or the need for mitral valve repair or replacement in patients with anomalous origin of the left coronary artery from the pulmonary artery? [PDF]

, 2008
John W. Brown, Mark Ruzmetov, John J. Parent, Mark D. Rodefeld, Mark W. Turrentine   +4 more
openalex   +1 more source

Building an Intelligent Cardiovascular System Platform: Embedding Artificial Intelligence across All Facets of Cardiovascular Medicine

Advanced Intelligent Systems, EarlyView.
This paper presents an integrated AI‐driven cardiovascular platform unifying multimodal data, predictive analytics, and real‐time monitoring. It demonstrates how artificial intelligence—from deep learning to federated learning—enables early diagnosis, precision treatment, and personalized rehabilitation across the full disease lifecycle, promoting a ...
Mowei Kong, Xingwei Zhao, Qiuting Li, Yang Yu, Chunxiang Zhang   +4 more
wiley   +1 more source

Lipopolysaccharide acutely suppresses right‐ventricular strain in rats with pulmonary artery hypertension [PDF]

, 2017
Junjie Zhang, Yanan Cao, Xiaowei Gao, Maoen Zhu, Zhong Zhang, Yue Yang, Qulian Guo, Yonggang Peng, E Wang   +8 more
openalex   +1 more source

Impact of Secondary Prevention on Mortality in the Building Trades National Medical Screening Program: Effectiveness of Occupational High‐Risk Management

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Since 1997 the Building Trades National Medical Screening Program (BTMed) has offered medical exams to construction workers employed in US nuclear weapons facilities. The process consists of two steps: (1) a detailed work history interview; and (2) a medical exam.
Knut Ringen, John M. Dement, Marianne Cloeren, Sammy Almashat, William Grier, Stella Hines, Laura S. Welch, Kim Cranford, Scott Haas, Patricia Quinn, Anna Chen, Miles Fisher   +11 more
wiley   +1 more source

Rare case report of main pulmonary artery occupying lesion: pulmonary artery intimal sarcoma. [PDF]

Eur Heart J Case Rep
Liu L, Chen L, Chen H, Yao J, Fang A.
europepmc   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source