Results 61 to 70 of about 2,608,517 (407)

Targeting IL-11 system as a treatment of pulmonary arterial hypertension

Pharmacological Research, 2023
IL-11 is linked to fibrotic diseases, but its role in pulmonary hypertension is unclear. We examined IL-11's involvement in idiopathic pulmonary arterial hypertension (iPAH).
Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá, Francisco Perez-Vizcaino, Julio Cortijo   +6 more
doaj   +1 more source

Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension [PDF]

, 2017
Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces
Harvey, Adam P., Hood, Katie Y., MacLean, Margaret R., Mair, Kirsty M., Montezano, Augusto C., Touyz, Rhian M.   +5 more
core   +2 more sources

Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension

Circulation. Cardiovascular Interventions, 2015
Background—Pulmonary arterial hypertension is a devastating disease with high morbidity and mortality and limited treatment options. Recent studies have shown that pulmonary artery denervation improves pulmonary hemodynamics in an experimental model and ...
A. Rothman, N. Arnold, W. Chang, O. Watson, A. Swift, R. Condliffe, C. Elliot, D. Kiely, S. Suvarna, J. Gunn, A. Lawrie   +10 more
semanticscholar   +1 more source

Development of a personalized visualization and analysis tool to improve clinical care in complex multisystem diseases with application to scleroderma

Arthritis Care &Research, Accepted Article.
Background In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of a scleroderma patient's ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

A rare case of intercostal-to-pulmonary artery fistula and its endovascular treatment in the setting of post pulmonary tuberculosis bronchiectasis and haemoptysis

South African Journal of Radiology
Intercostal artery-to-pulmonary artery fistula is an extremely rare variant of systemic artery-to-pulmonary artery fistulas (SA-PAFs). A case of a 38-year-old man presenting with clinically significant haemoptysis secondary to an intercostal artery-to ...
Lwandile Majozini, Winile Nkosi
doaj   +1 more source

Microscopic feature of lymph node anthracosilicosis adherent with pulmonary artery: a case report

Journal of Cardiothoracic Surgery, 2023
Background Although thoracic surgeons occasionally encounter dense adhesions of interlobar lymph node anthracosilicosis with the pulmonary artery, adhesiolysis may be challenging. Besides, characteristic microscopic features of the adherent lesion remain
Junichi Murakami, Toshiki Tanaka, Yoshinobu Hoshii, Kimikazu Hamano   +3 more
doaj   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Isolated congenital interruption of the right interlobar pulmonary artery with unilateral interstitial lung abnormality

Respiratory Medicine Case Reports, 2022
We report a case of an isolated congenital interruption of the right interlobar pulmonary artery with unilateral interstitial lung abnormality. 3D-CT with enhancement showed absent right interlobar pulmonary artery without any other abnormalities of the ...
Mitsukuni Sakabe, Kazunori Tobino, Kazuki Uchida, Yosuke Murakami, Yuri Hiramatsu, Hiroaki Ota, Takafumi Kawabata   +6 more
doaj   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Pulmonary Artery Dissection Following Severe Pulmonary Artery Hypertension

, 2017
Background: Arterial dissection is caused by in-vessel hemorrhages, either secondary to intimal ruptures, to laceration or other pathology of the vasa vasorum.The dissection leads to the formation of a false dissecting lumen.
A. Diasmada
semanticscholar   +1 more source