Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang +7 more
wiley +1 more source
Comprehensive assessments of pulmonary circulation in children with pulmonary hypertension associated with congenital heart disease. [PDF]
Front Pediatr, 2022 Muneuchi J +3 more
europepmc +1 more source
Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models
Animal Models and Experimental Medicine, EarlyView.We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv +12 more
wiley +1 more source
Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation. [PDF]
Int J Mol Sci, 2022 Nagaraj C +7 more
europepmc +1 more source
AI-Enabled Accurate Non-Invasive Assessment of Pulmonary Hypertension Progression via Multi-Modal Echocardiography [PDF]
arXivEchocardiographers can detect pulmonary hypertension using Doppler echocardiography; however, accurately assessing its progression often proves challenging. Right heart catheterization (RHC), the gold standard for precise evaluation, is invasive and unsuitable for routine use, limiting its practicality for timely diagnosis and monitoring of pulmonary ...
arxiv
Changes in the Pulmonary Circulation after Bronchial Occlusion in Anesthetized Dogs and Cats [PDF]
, 1969 Gwenda R. Barer +3 more
openalex +1 more source
A mouse model of lung ischemia–reperfusion injury with reversible left hilar entrapment
Animal Models and Experimental Medicine, EarlyView.A Novel Reversible Left Hilar Entrapment Model for Mouse Lung Ischemia‐Reperfusion Injury with Visual Tracheal Intubation and Live Knot Technique. Abstract Lung ischemia–reperfusion injury (LIRI), an acute lung injury syndrome triggered by lung transplantation or distal organ ischemia, has long been a difficult and hot issue in clinical research.
GuangDong Weng +4 more
wiley +1 more source
Pulmonary circulation abnormalities in post-acute COVID-19 syndrome: dual-energy CT angiographic findings in 79 patients. [PDF]
Eur Radiol, 2023 Mohamed I +8 more
europepmc +1 more source
Bronchovascular Tree-Guided Weakly Supervised Learning Method for Pulmonary Segment Segmentation [PDF]
arXivPulmonary segment segmentation is crucial for cancer localization and surgical planning. However, the pixel-wise annotation of pulmonary segments is laborious, as the boundaries between segments are indistinguishable in medical images. To this end, we propose a weakly supervised learning (WSL) method, termed Anatomy-Hierarchy Supervised Learning (AHSL),
arxiv