Results 91 to 100 of about 269,597 (228)

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Microbiological features of bronchial asthma and chronic obstructive pulmonary disease during remission

Клиническая практика, 2018
Background: Bronchial asthma and chronic obstructive pulmonary disease are currently the fifth leading cause of death in the world. The combination of bronchial asthma and chronic obstructive pulmonary disease seems to be a unique disease resulting from ...
M. Yu. Smirnova-Saprytskaya, G. L. Osipova, T. P. Ospelnikova, G. A. Danilina, K. A. Zykov   +4 more
doaj   +1 more source

Ligand‐Driven Annular‐Epitaxial Growth of CuS‐Au Heterostructures as Trinity Plasmonic Nanozyme for Multimode Diagnosis of Pathogenic Bacteria

Advanced Science, EarlyView.
CuS‐Au heterostructures were synthesized via ligand‐regulated annular‐epitaxial growth strategy, biotin‐Concanavalin A (ConA) was modified on the CuS‐Au heterostructures for universal bacterial‐labelling, assembled with strip, Streptococcus pneumoniae and Klebsiella pneumoniae can be sensitively recognized by SERS/colorimetric/temperature three‐mode ...
Xiaorui Lin, Pengyou Zhou, Miao An, Chenyi Zhu, Yuanfeng Pang, Rui Xiao   +5 more
wiley   +1 more source

Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences

International Journal of COPD, 2009
Carlos Zamarrón1, Vanesa García Paz1, Emilio Morete1, Felix del Campo Matías21Servicio de Neumología, Hospital Clínico Universitario de Santiago, Santiago, Spain; 2Servicio de Neumologia, Hospital ...
Carlos Zamarrón, Vanesa García Paz, Emilio Morete, Felix del Campo Matías   +3 more
doaj  

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Clinics, 2019
The relationship between surfactant-associated protein D polymorphisms and chronic obstructive pulmonary disease risk remains controversial. This article is the first to systematically evaluate this relationship.
Yi Liao, ChengLiang Huang, JianRong Wang, XianMing Fan   +3 more
doaj   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

FORECASTING CORONARY EVENTS BASED ON THE ANALYSIS OF THE DYNAMICS OF MORPHOFUNCTIONAL PARAMETERS OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN THE NORTH

Архивъ внутренней медицины, 2018
In modern society, chronic obstructive pulmonary disease has been isolated relatively recently in an independent nosological unit and, along with cardiovascular diseases, constitutes the leading group of  socially significant chronic diseases, being one ...
D. A. Dolgopolova, M. A. Popova, N. N. Terentyeva   +2 more
doaj   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source

Sputum colour charts to guide antibiotic self-treatment of acute exacerbation of chronic obstructive pulmonary disease: the Colour-COPD RCT

Health Technology Assessment
Background Chronic obstructive pulmonary disease exacerbations (acute exacerbation of chronic obstructive pulmonary disease) are characterised by increased sputum volume, purulence and breathlessness.
Eleni Gkini, Rachel L Adams, Daniella Spittle, Paul Ellis, Katherine Allsopp, Sanya Saleem, Matthew McKenna, Nick le Mesurier, Nicola Gale, Sarah Tearne, Peymane Adab, Rachel E Jordan, Nawar Diar Bakerly, Alice M Turner   +13 more
doaj   +1 more source