Results 71 to 80 of about 794,216 (288)
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
, 2020 clinical practice T h e n e w e ng l a n d j o u r na l o f m e dic i n e A 62-year-old man presents with a three-day history of progressive dyspnea, nonproductive cough, and low-grade fever.
M.D Lorraine B Ware +1 more
core +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Journal of Research in Pharmacy Practice, 2016 Objective: Methadone poisoning is common in our society, mainly in drug addicts. One of its lethal complications is pulmonary edema. Therefore, we evaluated the prevalence of pulmonary edema in the deceased cases with methadone poisoning and its possible
Nastaran Eizadi-Mood +4 more
doaj +1 more source
EXPERIMENTAL PULMONARY EDEMA [PDF]
Archives of Internal Medicine, 1920 The following summary of the literature on pulmonary edema is to serve as a background for the present great interest in pulmonary edema stimulated by the work done on gas poisoning in the battle areas and in the laboratories. It was decided that the purpose of our work could be best fulfilled if an accurate recital of the experiments and data on ...
openaire +1 more source
Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery
Advanced Science, EarlyView.Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie +11 more
wiley +1 more source
Postoperative Pulmonary Edema Conundrum: A Case of Negative Pressure Pulmonary Edema
Case Reports in Critical Care, 2018 Postobstructive pulmonary edema (POPE) also known as negative pressure pulmonary edema (NPPE) is an underdiagnosed entity in clinical practice and can lead to life-threatening hypoxemia.
Pramod K. Guru +4 more
doaj +1 more source
Experimental Biology and Medicine, 1936 The frequent occurrence of pulmonary edema as one of the characteristic pathological findings in experimental shock, and following the shock syndrome in human cases, suggested methods by which it might be reproduced. Widespread congestion and petechial hemorrhages predominate as visible changes in rapidly developing shock while in cases in which the ...
VIRGIL H. MOON, DAVID R. MORGAN
openaire +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
New insights in the pathogenesis of high-altitude pulmonary edema
, 2010 High-altitude pulmonary edema is a life-threatening condition occurring in predisposed but otherwise healthy individuals. It therefore permits the study of underlying mechanisms of pulmonary edema in the absence of confounding factors such as coexisting ...
Allemann, Yves +9 more
core +1 more source