Results 111 to 120 of about 27,531 (209)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

An unusual cause of progressive dyspnoea, pulmonary nodules and pleural effusions

open access: yesRespirology Case Reports
Eosinophilic granulomatosis with polyangiitis (EGPA) is part of the ANCA‐associated vasculitides, although ANCA‐negative presentations are not infrequent.
Sudharsan Venkatesan   +3 more
doaj   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li   +4 more
wiley   +1 more source

Clinical Factors Associated With Non‐Completion of Durvalumab Maintenance Therapy After Chemoradiotherapy in Patients With Locally Advanced Non‐Small Cell Lung Cancer: A Single‐Center Retrospective Study

open access: yesThoracic Cancer, Volume 17, Issue 12, June 2026.
Among 80 patients with locally advanced NSCLC receiving durvalumab after CCRT, 44 patients (55%) did not complete 12 months of treatment. Lower A/G ratio and higher RDW‐SD before durvalumab initiation may serve as exploratory signals for non‐completion, closer monitoring, and supportive care planning.
Masaaki Kotake   +4 more
wiley   +1 more source

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

open access: yesContact Dermatitis, Volume 94, Issue 6, Page 677-688, June 2026.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli   +8 more
wiley   +1 more source

Respiratory Biomarkers: An Opportunity for Patient‐Centric Microsampling Approach for Treatment Optimization

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
Overview of patient centric microsampling approach for monitoring respiratory biomarkers for treatment optimization. Image created in BioRender. Khan, A. (2026) https://BioRender.com/17jm5cs. ABSTRACT The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy.
Ahmar Khan   +4 more
wiley   +1 more source

Oral Angiolymphoid Hyperplasia With Eosinophilia Exhibiting Cutaneous‐Type Histopathologic Features: Clinical Regression Following Hormonal Withdrawal and a 50‐Year Review

open access: yesJournal of Cutaneous Pathology, Volume 53, Issue 6, Page 491-501, June 2026.
Case report of a 30‐year‐old female. Asymptomatic, red‐purple hyperplastic lesion extending from teeth 21 to 25, with bleeding upon manipulation. Differential diagnosis included: inflammatory gingival hyperplasia, plasma cell gingivitis, leukemia, and Wegener's granulomatosis.
Pedro Vinícius Santos de Jesus   +8 more
wiley   +1 more source

Gossypiboma‐associated sarcomas in five cases

open access: yesJournal of Small Animal Practice, Volume 67, Issue 6, Page 520-527, June 2026.
Objectives To report clinical presentation, treatment and outcome of dogs and cats diagnosed with gossypiboma‐associated sarcoma. Materials and Methods Referral centres within the United Kingdom, Europe, North America and Australia were contacted to search medical records for dogs and cats with documented gossypiboma‐associated sarcoma and included if ...
G. Thomas   +8 more
wiley   +1 more source

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