Results 41 to 50 of about 15,984 (194)

Molecular IgE Sensitization Profiling With Micro‐Arrayed Allergen Molecules in Adult Patients With Asthma From the LEAD Cohort: A Precision Medicine Approach

Allergy, EarlyView.
In the LEAD cohort, micro‐arrayed asthma allergens identified IgE‐sensitized adult asthma patients. Compared to non‐IgE‐sensitized patients, they had better lung function, took less ICS and had lower eosinophils. IgE‐sensitized patients were sensitized to a handful of respiratory allergen sources and may benefit from allergen‐specific forms of ...
Huey‐Jy Huang, Robab Breyer‐Kohansal, Katarzyna Niespodziana, Charmaine J. M. Lim, Marie‐Kathrin Breyer, Rudolf Valenta, Sylvia Hartl, the Allergochip Working Group, Maria‐Roxana Buzan, Kuan‐Wei Chen, Monica Daniela Cotarcă, Alexandra Dubovets, Pia Gattinger, Alexander Karaulov, Evgenii Kozlov, Carmen Panaitescu, Daria Trifonova, Mikhail Tulaev, Susanne Vrtala, Milena Weber, Lauriana‐Eunice Zbîrcea   +20 more
wiley   +1 more source

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]

, 2016
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank, Barrett, Nora A, Kanaoka, Yoshihide, Locksley, Richard M, O'Leary, Claire E, von Moltke, Jakob   +5 more
core   +1 more source

Emapalumab for Maladaptive Interferon‐γ‐Mediated Inflammation in Drug Reaction With Eosinophilia and Systemic Symptoms Complicating First‐Line Antituberculosis Therapy

Pediatric Blood &Cancer, EarlyView.
Yahya Almodallal, Daniel Whitehurst, Sing Sing Way, Jane Koo, Ashish R. Kumar   +4 more
wiley   +1 more source

Myeloid cAMP Reduction Shifts Rhinovirus‐Induced Airway Inflammation From Neutrophilic to Eosinophilic by Suppressing M1‐Interstitial Macrophages

Allergy, EarlyView.
ABSTRACT Background Asthma exacerbations caused by human rhinovirus (hRV) infection are characterized by airway neutrophilia and reduced corticosteroid response, leading to significant healthcare costs and lung function impairment. The Gαs subunit of the trimeric G protein regulates immunopathological conditions by modulating cAMP levels.
Seong Ok Park, Erdenebileg Uyangaa, Hyo Jin Kim, Hee Won Byeon, Jin Young Choi, Koanhoi Kim, Jihyung Lee, Samuel Bertin, Eyal Raz, Seong Kug Eo   +9 more
wiley   +1 more source

Adult human case of toxocariasis with pulmonary migratory infiltrate and eosinophilia [PDF]

, 2011
Introduction. Toxocariasis is a zoonosis which is in Serbia characterized with a very high infection rate of dogs and excessive contamination of the soil with the eggs of Toxocara canis, the agent of the disease.
Lalošević Dušan, Lalošević Vesna, Považan Anika, Považan Đorđe, Sečen Svetozar, Uzurov-Dinić Vera, Đurić Mirna   +6 more
core   +1 more source

Septic Shock Caused by Small Bowel Ischemia in Eosinophilic Granulomatosis With Polyangiitis

United European Gastroenterology Journal, EarlyView.
Vlad Pavel, Patricia Mester, Florian Weber, Martina Müller, Stephan Schmid   +4 more
wiley   +1 more source

Anti‐IL‐5 Vaccination Dampens Allergen‐Specific IgE Levels and Modulates IL‐4 and IL‐5 Th2 Cytokines in Skin Allergy of Mice and Horses

Allergy, EarlyView.
This study investigates the effect of IL‐5 vaccination on allergen‐specific IgE levels, as well as mRNA and protein expression of Th1/Th2‐associated cytokines using a murine OVA skin allergy model and the naturally occurring skin allergy IBH in horses.
Fadi Jebbawi, Florian Olomski, Victoria Inversini, Giulia Keller, Tanya Rhiner, Nina Waldern, Juwela Lam, Stanislav Pantelyushin, Fabia Canonica, Katharina Birkmann, Pål Johansen, Thomas M. Kündig, Antonia Fettelschoss‐Gabriel   +12 more
wiley   +1 more source

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]

, 2015
Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds
AT Nathan, B Schaub, BA Fallert, Bart N. Lambrecht, Bernhard Ryffel, Beth A. Fallert Junecko, BN Lambrecht, BN Lambrecht, BN Lambrecht, BR O'Driscoll, C Braun-Fahrlander, CE Reed, David L. Williams, DC Newcomb, EC Cates, F Gerosa, F Kirstein, Frank Brombacher, Frank Kirstein, G Trinchieri, GD Brown, Gordon D. Brown, GP Anderson, Graeme Murray, H Hammad, HE Ensley, HS Goodridge, I Agache, J Chakir, J Douwes, J Thorn, J Zhao, Jay K. Kolls, JB Allard, JH Bonlokke, JL Simpson, Kaat Fierens, KM Dennehy, KM Dennehy, Kong Chen, L Dong, L McKinley, LG Gregory, LK Fogli, LM Lilly, M Kudo, M Laan, M Plantinga, M Rosas, N Pearce, NN Jarjour, PC Porter, Pierre Redelinghuys, PJ Barnes, R Rylander, RA Drummond, RA Martin, RA Mintz-Cole, RA Mintz-Cole, Rebecca A. Drummond, RH Wilson, S Ano, S Saad-El-Din Bessa, Sabelo Hadebe, Sara Sajaniemi, SC Cheng, SC Eisenbarth, Simon Vautier, Todd A. Reinhart, W Eder, WC Moore, ZZ Pan   +71 more
core   +8 more sources

An Algorithm for the Diagnosis and Management of Severe Asthma in Children and Adolescents

Allergy, EarlyView.
ABSTRACT Severe asthma (SA) in childhood is infrequent (≈2% of all paediatric asthma), yet it drives a disproportionate share of morbidity and cost. A clear algorithm is required to distinguish difficult‐to‐treat asthma (DTA) from true SA and to guide phenotype‐driven diagnosis and therapy.
Eckard Hamelmann, Bianca Schaub, Susanne Lau, Leonard B. Bacharier   +3 more
wiley   +1 more source

Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases

Allergy, EarlyView.
Primary peripheral blood‐derived human mast cells exposed to IFNγ, IL‐33, IL‐4 + IL‐13, or TGFβ develop distinct transcriptional signatures with unique functional changes including degranulation and cytokine/chemokine release. Machine learning‐defined minimal cytokine‐activated signatures (245 genes) successfully detect cytokine‐primed mast cells in ...
Chiara Tontini, Rajia Bahri, Andrew Higham, Dave Singh, Angela Simpson, Silvia Bulfone‐Paus   +5 more
wiley   +1 more source