Results 141 to 150 of about 412,177 (358)

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. [PDF]

, 2019
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares
Ahadome, Sarah D, Aros, Cody J, Bhatt, Kush V, Chung, Katherine, Clark, Amander T, Damoiseaux, Robert, Darmawan, Kelly F, Durra, Abdo, Gomperts, Brigitte N, Graeber, Thomas G, Karumbayaram, Saravanan, Manze, Chase C, Mehrabi, Mehrsa, Minasyan, Aspram, Paul, Manash K, Rickabaugh, Tammy M, Sandlin, Jenna M, Shia, David W, Vijayaraj, Preethi, Wallace, W Dean, Wilkinson, Dan C, Yan, Weihong   +21 more
core   +1 more source

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

Advanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun, Mengyuan Wang, Lin Liu, Ruiyang Ding, Kanglin Yan, Shiqian Liu, Xiaoke Ren, Qing Xu, Zhiwei Sun, Qian Liu, Yi Yang, Junchao Duan   +11 more
wiley   +1 more source

Pyroptosis-related signatures predict immune characteristics and prognosis in IPF

Heliyon
The purpose of this work was to use integrated bioinformatics analysis to screen for pyroptosis-related genes (PRGs) and possible immunological phenotypes linked to the development and course of IPF.
Yijun He, Tingting Yao, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiangyu Zhang, Xin Lv, Yuanyuan Han, Xiaoyun Cheng, Mengyu Li, Mao Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng   +13 more
doaj   +1 more source

A perspective view on widespread pulmonary fibrosis. [PDF]

, 1974
M Turner‐Warwick
openalex   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Advanced Science
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The
Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Ruoyu Duan, Zhihua Ji, Xiaoyue Pan, Yanlin Zhou, Guoying Yu, Lan Wang   +9 more
doaj   +1 more source

Plasma levels of chemokines decrease during elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis

Heliyon
Background: Cystic fibrosis (CF) is associated with dysregulated immune responses, exaggerated inflammation and chronic infection. CF transmembrane conductance regulator (CFTR) modulator therapies directly target the underlying protein defects and ...
Dirk Westhölter, Johannes Pipping, Jonas Raspe, Mona Schmitz, Sivagurunathan Sutharsan, Svenja Straßburg, Matthias Welsner, Christian Taube, Sebastian Reuter   +8 more
doaj   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

Pindolol and pulmonary fibrosis. [PDF]

, 1979
P. Krupp, J. M. Crawford
openalex   +1 more source