Results 141 to 150 of about 789,217 (259)
DiseasesIdiopathic pulmonary fibrosis (IPF) imposes a substantial symptom burden that adversely impacts patients’ quality of life. Current anti-fibrotic treatments for IPF provide limited symptomatic relief, necessitating the implementation of complementary ...
Neha Shah
doaj +1 more source
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma
Advanced Science, EarlyView.MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang +5 more
wiley +1 more source
A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects
Advanced Science, EarlyView.Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song +13 more
wiley +1 more source
Advanced Science, EarlyView.The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma +12 more
wiley +1 more source
, 2014 Steven D Nathan, Christopher S King Advanced Lung Disease Clinic, Inova Fairfax Hospital, Falls Church, VA, USA Abstract: Idiopathic pulmonary fibrosis (IPF) is a disease that carries a high mortality.
King CS, Nathan SD
core
Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems
Advanced Science, EarlyView.The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan +3 more
wiley +1 more source
Advanced Science, EarlyView.Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin +5 more
wiley +1 more source
The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization
Advanced ScienceAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The
Bin Li +9 more
doaj +1 more source