Results 181 to 190 of about 279,445 (313)

Emerging Therapies in Pulmonary Fibrosis. [PDF]

Pulm Ther
Etchingham-Coll H, Temizel E, Okezie-Enyioma N, Martin N, Kaenmuang P, Coghlan S, Spagnolo P, Chaudhuri N.   +7 more
europepmc   +1 more source

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

Sex Disparity in Systemic Sclerosis-Associated Pulmonary Fibrosis. [PDF]

Int J Mol Sci
Galimba AN, Renaud L, Kotz SE, Herzog EL, Feghali-Bostwick C.   +4 more
europepmc   +1 more source

Demystifying pulmonary fibrosis [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020
openaire   +2 more sources

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Exploring the role of RCEO in macrophage-mediated modulation of pulmonary fibrosis. [PDF]

Chin Med
Mao Z, Lin X, Yang X, Liu Y, Han C, Tian S, Song Y, Zhao H, Miao M.   +8 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

B and T cells in lung tissue are associated with smoking and forced vital capacity in idiopathic pulmonary fibrosis and familial pulmonary fibrosis. [PDF]

Respir Res
Jaula H, Kreus M, Heikkinen A, Leppänen J, Lappi-Blanco E, Vähänikkilä H, Harju T, Kaarteenaho R.   +7 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source