Results 171 to 180 of about 402,863 (300)

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

The intersection of liver cirrhosis and pulmonary fibrosis. [PDF]

J Transl Med
Bayraktar EA, Salvatore M.
europepmc   +1 more source

Animal models of chronic thromboembolic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu, Lin‐Chao Zhou, Xiao‐Xue Zhang, Xiao‐Yang Ren, Yi Yan, Shao‐Fei Liu   +5 more
wiley   +1 more source

Decoding macrophage heterogeneity in the pulmonary fibrosis lung cancer transition. [PDF]

Front Immunol
Yu H, Zhao M, Li Q, Zhang Y.
europepmc   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

RIPK3 Orchestrates Scar-Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis. [PDF]

Adv Sci (Weinh)
Yang T, Li X, Lei S, Li Q, Zhang Y, Hui Z, Ren J, Yang X, Yang X, Feng C, Xu Y, Zhao D, Tang W.   +12 more
europepmc   +1 more source

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling [PDF]

, 2017
Chen, Lin, Dorry, Samuel J, Guzy, Robert D, Koo, Hyun Young, Li, Ling, Ornitz, David M, Smith, Craig   +6 more
core   +2 more sources

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

A Lung-Targeted Carrier of Carbon Monoxide for Idiopathic Pulmonary Fibrosis Therapy. [PDF]

ACS Nano
Guo W, Huang S, Zhang J, Zhang X, Yang J, Bao Y, Zhang J.   +6 more
europepmc   +1 more source

Acquired whole-lung mismatched perfusion defects on pulmonary ventilation/perfusion scintigraphy [PDF]

, 2018
Alberg, Holmes, Pickhardt, Raghu, Rossi, Saad, Slonim, Sostman   +7 more
core   +2 more sources