Results 281 to 290 of about 280,725 (312)
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Pathobiology of pulmonary fibrosis
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1990Pulmonary fibrosis is characterized by an increase in lung matrix and alterations in the numbers and spatial relationships of lung parenchymal cells. The increase in matrix results from a proliferation and “activation” of fibroblasts (FB) with increased production and deposition of matrix macromolecules at sites of lung injury.
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Autophagy and Pulmonary Fibrosis
2020Pulmonary fibrosis is a progressive chronic inflammatory disease with a poor clinical outcome. Although pirfenidone and nintedanib have been approved by FDA to treat idiopathic pulmonary fibrosis (IPF), these drugs can only slow the progression of IPF. Autophagy plays an important role in the pathogenesis of pulmonary fibrosis.
Xiaoxi, Lv, Ke, Li, Zhuowei, Hu
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Macrophages and Pulmonary Fibrosis
Current Molecular MedicineMost chronic respiratory diseases often lead to the clinical manifestation of pulmonary fibrosis. Inflammation and immune disorders are widely recognized as primary contributors to the onset of pulmonary fibrosis. Given that macrophages are predominantly responsible for inflammation and immune disorders, in this review, we first focused on the role ...
Shengjun, Chen +2 more
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Pulmonary Fibrosis and Emphysema
The Indian Journal of Chest Diseases and Allied Sciences, 2022Julpikar Ali, Sarkavas +2 more
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Clinics in Chest Medicine, 1982
SUMMARY Idiopathic pulmonary fibrosis is a precise syndrome defined by clinical, roentgenographic, physiologic, and histopathologic features. Clinically, most patients have a nonproductive cough and dyspnea on exertion. The most common physical finding is the presence of crackles over the lower portions of both lungs; also, there may be clubbing ...
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SUMMARY Idiopathic pulmonary fibrosis is a precise syndrome defined by clinical, roentgenographic, physiologic, and histopathologic features. Clinically, most patients have a nonproductive cough and dyspnea on exertion. The most common physical finding is the presence of crackles over the lower portions of both lungs; also, there may be clubbing ...
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Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis
New England Journal of Medicine, 2022Toby Maher +2 more
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