Results 141 to 150 of about 868,554 (359)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Role of a New Walk Test in Pulmonary Arterial Hypertension: A Retrospective Cohort Study

Pulmonary Circulation
The 6‐min walk test (6MWT) has significant prognostic value, but requires long walking distances and lacks evaluation of exercise speed. This study aimed to investigate the clinical utility of a new walk test, the 18‐meter walk test (18MWT), in patients ...
Junhao Jin, Yao Mi, Aqian Wang, Bo Li, Kaiyu Jiang, Hai Zhu, Ting Liang, Hongling Su, Yunshan Cao   +8 more
doaj   +1 more source

Pathophysiology and Diagnosis of Pulmonary Hypertension Due to Left Heart Disease [PDF]

, 2018
Athanasios Charalampopoulos, Robert A. Lewis, Peter Hickey, Charlotte Durrington, Charlie Elliot, Robin Condliffe, Ian Sabroe, David G. Kiely   +7 more
openalex   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Adult Congenital Heart Disease

JACC: Case Reports, 2021
Margarita Brida, MD, PhD, Michael A. Gatzoulis, MD, PhD   +1 more
doaj   +1 more source

Chinese herbal medicine injections (CHMIs) for chronic pulmonary heart disease: A protocol for a Bayesian network meta-analysis. [PDF]

Medicine (Baltimore), 2021
Lei Y, Wang M, Sun G, Liu Y, Yang Y, Hao D.   +5 more
europepmc   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

"Yiqi Huayu, Wenyang Lishui" Prescription (YHWLP) Improves the Symptoms of Chronic Obstructive Pulmonary Disease-Induced Chronic Pulmonary Heart Disease by Inhibiting the RhoA/ROCK Signaling Pathway. [PDF]

Evid Based Complement Alternat Med, 2021
Huang H, Shan K, Cai M, Chen H, Wu F, Zhao X, Zhuang H, Li H, Shi S.   +8 more
europepmc   +1 more source

Diagnosing heart failure with preserved ejection fraction with pulmonary vascular disease [PDF]

, 2022
Micha T. Maeder
openalex   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source