Results 161 to 170 of about 868,554 (359)
Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu +18 more
wiley +1 more source
Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha +13 more
wiley +1 more source
Patent ductus arteriosus (PDA) is a common congenital heart disease, presenting with symptoms of increased pulmonary blood flow in infancy and childhood.
Susheel Kumar Malani +3 more
doaj +1 more source
Pulmonary arterial wall distensibility assessed by intravascular ultrasound in children with congenital heart disease: an indicator for pulmonary vascular disease? [PDF]
BACKGROUND: Both pulmonary hypertension and pulmonary overflow are associated with functional and structural changes of the pulmonary arterial wall.
Berger, R.M.F. (Rolf) +4 more
core
MR imaging of non-visualized pulmonary arteries at angiography in patients with congenital heart disease [PDF]
Yon Ho Choe +5 more
openalex +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
TRICUSPID AND PULMONARY VALVES RESEMBLING CARCINOID HEART DISEASE IN METHAMPHETAMINE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION [PDF]
Andrea Mytinger +2 more
openalex +1 more source
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu +17 more
wiley +1 more source

