Results 21 to 30 of about 164,448 (358)
Magnetic wire active microrheology of human respiratory mucus [PDF]
Soft Matter, 2021,17, 7585-7595, 2021 Mucus is a viscoelastic gel secreted by the pulmonary epithelium in the tracheobronchial region of the lungs. The coordinated beating of cilia moves mucus upwards towards pharynx, removing inhaled pathogens and particles from the airways. The efficacy of this clearance mechanism depends primarily on the rheological properties of mucus.
arxiv +1 more source
The Complex Interplay of Pulmonary Kinetic Processes [PDF]
, 2018 The inhalation route is frequently used to administer drugs for the management of respiratory diseases such as asthma or chronic obstructive pulmonary disease.
Borghardt, Jens Markus +2 more
core +1 more source
A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]
, 2016 The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth +2 more
core +1 more source
Respimat as the new standard for inhalation therapy devices
Медицинский совет, 2021 The effectiveness of inhalation therapy can be significantly reduced by a number of problems. For example, inhalation technique errors can reduce the dose delivered by 22-95% compared to the optimal value in patients with technical errors in the use of ...
V. V. Arkhipov
doaj +1 more source
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs [PDF]
, 2020 The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic (PK) processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Although each single process has been systematically investigated, a quantitative understanding on their interaction remains limited and hence identifying optimal drug and ...
arxiv +1 more source
Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats [PDF]
, 2016 The increasing use of silver nanoparticles (AgNPs) in consumer products is concerning. We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to Sprague-Dawley (SD) rats.We determined the ...
Buckley, A +17 more
core +1 more source
Multifunctional nanocarriers for lung drug delivery [PDF]
, 2020 Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
core +2 more sources
Intensive Care Medicine Experimental, 2021 Background The effects of selective pulmonary vascular tone alterations on cardiac preload have not been previously examined. Therefore, we evaluated whether changing pulmonary vascular tone either by hypoxia or the inhalation of aerosolized prostacyclin
Jaap Jan Vos +3 more
doaj +1 more source
Pulmonary Circulation, 2018 Inhaled iloprost efficiently improves pulmonary hemodynamics, exercise capacity, and quality of life in patients with pulmonary arterial hypertension (PAH). However, the process of inhalation is laborious for patients suffering from resting dyspnea.
Kazuhiko Nakayama +11 more
doaj +1 more source