Results 51 to 60 of about 104,967 (312)

Inhaled treprostinil and pulmonary arterial hypertension

Vascular Health and Risk Management, 2010
Multiple conditions result in development of pulmonary hypertension. Pulmonary arterial hypertension (PAH) is the subclassification of pulmonary hypertension, in which known or unknown underlying conditions lead to similar intrinsic alterations in the pulmonary vasculature.
Nadler, Samuel T, Edelman, Jeffrey D
openaire   +3 more sources

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

Particle and Fibre Toxicology, 2023
Background Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a major cause for concern.
Chelsea M Cary, Talia N Seymore, Dilpreet Singh, Kinal N Vayas, Michael J Goedken, Samantha Adams, Marianne Polunas, Vasanthi R Sunil, Debra L Laskin, Philip Demokritou, Phoebe A Stapleton   +10 more
doaj   +1 more source

ACUTE PULMONARY OEDEMA FOLLOWING SMOKE INHALATION

International Journal of Clinical Practice, 2000
SUMMARYA case of acute pulmonary oedema after smoke inhalation from a chip pan fire is presented. The role of bronchial and pulmonary circulation in the development of pulmonary oedema after smoke inhalation is discussed. We stress the importance not only of observation after smoke inhalation, as the manifestation of pulmonary oedema may be delayed ...
M, Saab, I, Majid
openaire   +2 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Vasodilatory effect of the stable vasoactive intestinal peptide analog RO 25-1553 in murine and rat lungs. [PDF]

PLoS ONE, 2013
Stable analogs of vasoactive intestinal peptide (VIP) have been proposed as novel line of therapy in chronic obstructive pulmonary disease (COPD) based on their bronchodilatory and anti-inflammatory effects.
Jun Yin, Liming Wang, Ning Yin, Arata Tabuchi, Hermann Kuppe, Gerhard Wolff, Wolfgang M Kuebler   +6 more
doaj   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration

Respiratory Research, 2005
Background The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats. Methods CD rats were given
Weissmann Norbert, Schudt Christian, Ghofrani Hossein, Yilmaz Hüseyin, Krick Stefanie, Pullamsetti Soni, Fuchs Beate, Seeger Werner, Grimminger Friedrich, Schermuly Ralph   +9 more
doaj   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Adults with well‐healed burn injuries have lower pulmonary function values decades after injury

Physiological Reports, 2022
Sub‐acute (e.g., inhalation injury) and/or acute insults sustained during a severe burn injury impairs pulmonary function. However, previous work has not fully characterized pulmonary function in adults with well‐healed burn injuries decades after an ...
Joseph C. Watso, Steven A. Romero, Gilbert Moralez, Mu Huang, Matthew N. Cramer, Manall F. Jaffery, Bryce N. Balmain, Daniel P. Wilhite, Tony G. Babb, Craig G. Crandall   +9 more
doaj   +1 more source