Results 31 to 40 of about 1,214,442 (354)

Additional Usefulness of Bronchoscopy in Patients with Initial Microbiologically Negative Pulmonary Tuberculosis: A Retrospective Analysis of a Korean Nationwide Prospective Cohort Study

Infection and Drug Resistance, 2022
Jee Youn Oh,1 Sung-Soon Lee,2 Hyung Woo Kim,3 Jinsoo Min,4 Yousang Ko,5 Hyeon-Kyoung Koo,2 Yun-Jeong Jeong,6 Hyeon Hui Kang,7 Ji Young Kang,8 Ju Sang Kim,3 Jae Seuk Park,9 Yunhyung Kwon,10 Jiyeon Yang,10 Jiyeon Han,10 You Jin Jang,10 Min Ki Lee,11 ...
Oh JY, Lee SS, Kim HW, Min J, Ko Y, Koo HK, Jeong YJ, Kang HH, Kang JY, Kim JS, Park JS, Kwon Y, Yang J, Han J, Jang YJ, Lee MK, Jegal Y, Kim YC, Kim YS   +18 more
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A Case of Inflammatory Lung Disease and Retroperitoneal Fibrosis Attributed to Systemic IgG4-related Disease [PDF]

, 2010
Recently, immunoglobulin (Ig) G4-related diseases such as autoimmune pancreatitis (AIP), sclerosingsialadenitis, retroperitoneal fibrosis, and sclerosing cholangitis have been reported.
Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Fumiya Fukushima, Hirokuni Hirata, Kazuhiro Kurasawa, Kouichi Honma, Kumiya Sugiyama, Kuniyoshi Kamiya, Makiko Anzai, Masamitsu Tatewaki, Reika Maezawa, Ryo Arai, Takeshi Fukuda, Yasutsugu Fukushima, Yoshiki Ishii, Yumeko Hayashi   +27 more
core   +1 more source

Clinical Characteristics and Medical Utilization of Smokers with Preserved Ratio Impaired Spirometry [Response to Letter]

International Journal of COPD, 2023
Yune-Young Shin,1 Sojung Park,1 Kyung Joo Kim,2 Chin Kook Rhee,2 Kwang Ha Yoo,3 Ki-Suck Jung,4 Jin Hwa Lee1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic ...
Shin YY, Park S, Kim KJ, Rhee CK, Yoo KH, Jung KS, Lee JH   +6 more
doaj  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia [PDF]

, 2013
Background and Objective:Chronic interstitial pneumonia (IP) might include chronic hypersensitivity pneumonitis (HP) and chronic bird-related hypersensitivity pneumonitis (BRHP).
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Fumito Oomi, Hirokuni Hirata, Kazuki Mashio, Kumiya Sugiyama, Naoya Ikeda, Naruo Yoshida, Takafumi Umetsu, Takeshi Fukuda, Yasutsugu Fukushima   +17 more
core   +1 more source

Treatment of symptomatic endobronchial hamartoma by bronchoscopy

Revista de la Facultad de Ciencias Médicas de Córdoba
Hamartomas are benign tumors characterized by disorganized tissue native to a specific anatomical location. We present the case of a 61-year-old male with a history of COVID-19 infection who presented with a persistent cough.
María Emilia Cano, Felipe Pagnoncelli Fachin, José Carlos Felicetti   +2 more
doaj   +1 more source

The CO-MIND Study: Chronic Obstructive Pulmonary Disease Management in Daily Practice and Its Implications for Improved Outcomes According to GOLD 2019 Perspective

International Journal of COPD, 2022
Hakan Gunen,1 Nurdan Kokturk,2 Sibel Naycı,3 Sevket Ozkaya,4 Birsen Pınar Yıldız,5 Onur Turan,6 Aziz Gumus,7 Metin Akgun,8 Alev Gurgun,9 Candan Ogus,10 Arzu Mirici,11 Elif Sen,12 Nazan Bayram,13 Volkan Eken,14 Hakan Erkus14 ...
Gunen H, Kokturk N, Naycı S, Ozkaya S, Yıldız BP, Turan O, Gumus A, Akgun M, Gurgun A, Ogus C, Mirici A, Sen E, Bayram N, Eken V, Erkus H   +14 more
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Clinical Characteristics of Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Involvement of Viral, Mycoplasma pneumoniae, and Chlamydophila pneumoniae Infections [PDF]

, 2013
Background and Objective:To clarify the clinical characteristics of acute exacerbation of idiopathic pulmonaryfibrosis (IPF) and the involvement of infections with pathogenic microorganisms and viruses inacute exacerbation.Methods:During the 12 years ...
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Hirokuni Hirata, Kazuhiko Matsuno, Kazuki Obara, Kumiya Sugiyama, Makiko Anzai, Takeshi Fukuda, Yasuko Kikkawa, Yasutsugu Fukushima   +15 more
core   +1 more source