Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. [PDF]
, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Alkhazraji, Sondus +8 more
core +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.Invasive fungal infections (IFIs) are a leading cause of morbidity and mortality in children with hematological malignancies as well as those undergoing hematopoietic stem cell transplantation (HSCT). Extreme immunological dysregulation secondary to severe neutropenia, T‐cell lymphopenia, graft‐versus‐host disease (GVHD), intensive chemotherapy ...
Matin Pourghasem +11 more
wiley +1 more source
Pulmonary Artery Pseudoaneurysm Caused by Pulmonary Mucormycosis. [PDF]
Am J Respir Crit Care MedZhang M, Luo Q, Li X, Mu X, Wu W.
europepmc +3 more sources
Failure of voriconazole to cure disseminated zygomycosis in an immunocompromised child [PDF]
, 2018 Voriconazole is increasingly used as a first-line agent for empirical antifungal therapy of prolonged febrile neutropenia in paediatric cancer patients. We describe the case of a 9-year-old patient with stage IV Burkitt lymphoma, who developed pulmonary ...
Aebi, Christoph +6 more
core
Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints [PDF]
, 2016 OBJECTIVES: Isavuconazole, a novel triazole antifungal agent, has broad-spectrum activity against Aspergillus spp. and other pathogenic fungi. The isavuconazole exposure–response relationship in experimental invasive pulmonary aspergillosis using ...
Bonate, Peter +6 more
core +1 more source
Cytomegalovirus pneumonia with pulmonary mucormycosis
Indian Journal of Pathology and Microbiology, 2008 Solid organ transplantation is becoming increasingly common in the treatment of end-stage organ failure. However, despite improvements in patient and allograft survival, immunosuppression-induced compromised cell-mediated immunity predisposes transplant recipients to opportunistic infections.
Mysorekar Vijaya, Rao Saraswati
openaire +3 more sources
Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization
Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.We present a lethal case of Bourbon virus infection in a 63‐year‐old Caucasian, diabetic male who was previously in good health. The patient had spent time in the wooded areas of Bourbon County, Kansas, and removed three ticks from his body 5 days prior to presentation.
Allianna Mitchell +7 more
wiley +1 more source
Clinical characteristics and prognoses of pulmonary mucormycosis in four children
Pediatric Investigation, 2019 Importance Pulmonary mucormycosis is life threatening and carries a poor prognosis. Identification of factors that improve prognosis is urgently necessary.
Siyuan Guo +3 more
doaj +1 more source
Rhinocerebral zygomycosis in Pakistan: clinical spectrum, management, and outcome [PDF]
, 2011 OBJECTIVE: To study the disease spectrum and salient management features of 36 patients with histopathologically-confirmed rhinocerebral zygomycosis seen at our academic center over a 16-year period.
Ikram, Mubasher +5 more
core +1 more source
Rhino cerebral mucormycosis: a report of two cases and review of literature. [PDF]
, 2011 Mucormycosis is caused by fungi of the order Mucorales and is one of the fulminant and fatal mycotic infections known to human beings with a high mortality rate.
Ashish, Lanjekar +4 more
core +1 more source