Results 111 to 120 of about 201,410 (354)

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

open access: yesAdvanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin   +15 more
wiley   +1 more source

P1.4 HEMODYNAMICS OF PULMONARY HYPERTENSION: APPLICATION OF THE RESERVOIR-WAVE APPROACH

open access: yesArtery Research, 2015
Using the reservoir-wave approach, previously we characterized pulmonary vasculature mechanics with multiple interventions in a canine model. In the present study, we measured high-fidelity pulmonary arterial (PA) pressure, Doppler flow velocity, and ...
Anukul Ghimire*   +8 more
doaj   +1 more source

Critical appraisal of the instantaneous end‐diastolic pulmonary arterial wedge pressures

open access: yesESC Heart Failure, 2020
Aims A substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported.
Aristomenis Manouras   +4 more
doaj   +1 more source

Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization

open access: yesAdvanced Science, EarlyView.
Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li   +9 more
wiley   +1 more source

Update on pulmonary hypertension complicating chronic obstructive pulmonary disease

open access: yesInternational Journal of COPD, 2009
Soma Jyothula, Zeenat SafdarPulmonary-Critical Care Medicine, Baylor College of Medicine, Houston, TX, USAAbstract: Pulmonary hypertension (PH) is the hemodynamic manifestation of various pathological processes that result in elevated pulmonary artery ...
Soma Jyothula, Zeenat Safdar
doaj  

Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation

open access: yesAdvanced Science, EarlyView.
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Zhesong Deng   +12 more
wiley   +1 more source

Features of the left ventricle diastolic function in patients with community acquired pneumonia

open access: yesZaporožskij Medicinskij Žurnal, 2014
Introduction. One of the major factors considered unfavorable clinical course of central and peripheral hemodynamics, identifying them with a view to the timely correction, is a promising direction to improve prognosis in patients with community acquired
V. V. Syvolap, L. O. Kurilets
doaj   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

open access: yesAdvanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

Pulmonary artery pressure–perfusion relation during exercise in patients with chronic thromboembolic pulmonary hypertension using pulmonary arteriography and right-heart catheterization

open access: yesInternational Journal of Cardiology: Heart & Vasculature, 2023
Background: In pulmonary hypertension (PH), pulmonary artery pressure (PAP) does not increase to pulmonary perfusion (PP)  50% for the early detection of PP disorders.
Ayumi Goda   +6 more
doaj  

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