Results 151 to 160 of about 150,674 (346)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Use of a nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension

Терапевтический архив, 2010
Idiopathic (primary) pulmonary hypertension (IPH) is a rare disease of unknown etiology, which is characterized by elevated pulmonary artery pressure, increased total pulmonary vascular resistance, frequently a malignant course with evolving right ...
Ol'ga Aleksandrovna Arkhipova, Tamila Vital'evna Martynyuk, Valentina Kirillovna Lazutkina, Dil'bar Mukumovna Ataullakhanova, Ol'ga Vladimirovna Stukalova, Nikolay Mikhaylovich Danilov, Lyudmila Evgen'evna Samoylenko, Irina Evgen'evna Chazova, O A Arkhipova, T V Martynyuk, V K Lazutkina, D M Ataullakhanova, O V Stukalova, N M Danilov, L E Samoilenko, I E Chazova   +15 more
doaj  

Decoupling Between Diastolic Pulmonary Artery Pressure and Pulmonary Capillary Wedge Pressure as a Prognostic Factor After Continuous Flow Ventricular Assist Device Implantation

Circulation: Heart Failure, 2017
T. Imamura, B. Chung, A. Nguyen, D. Rodgers, G. Sayer, S. Adatya, N. Sarswat, Gene Kim, J. Raikhelkar, T. Ota, T. Song, Colleen Juricek, V. Kagan, V. Jeevanandam, M. Mehra, D. Burkhoff, N. Uriel   +16 more
semanticscholar   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Pulmonary Artery Wedge Pressure Can Underestimate Direct Pulmonary Vein Pressure in Pediatric Pulmonary Vein Stenosis

Journal of the Society for Cardiovascular Angiography & Interventions
Pulmonary artery wedge pressure (PAWP) can underestimate directly measured pulmonary vein pressure (PVP) as demonstrated in animal studies and human case reports. This concept has not been validated in a larger cohort of pediatric patients with pulmonary vein stenosis (PVS).Pediatric patients who underwent cardiac catheterization for PVS at a single ...
Ari J. Gartenberg, Michael L. O’Byrne, Ella B. Leeth, Jessica Tang, Mudit Gupta, Jonathan J. Rome, Ryan Callahan   +6 more
openaire   +2 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Comparative analysis of hemodynamic monitoring with pulmonary artery catheter and transthoracic echocardiography in patients with cardiogenic shock

Российский кардиологический журнал
Aim. To compare main central hemodynamic parameters obtained by pulmonary artery catheterization and transthoracic echocardiography (TTE).Material and methods.
V. V. Ryabov, A. G. Syrkina, M. A. Kercheva, I. I. Yolgin, O. O. Panteleev   +4 more
doaj   +1 more source

Elevated pulmonary capillary wedge pressure, higher blood pressure, and lower cardiac index in infants with bronchopulmonary dysplasia [PDF]

Catherine M. Avitabile, Xuemei Zhang, Steve Ampah, Yan Wang, Devon Ash, Kathleen Nilan, Jennifer E. Tingo, David B Frank, Erik A. Jensen, Krithika Lingappan, Kathleen Gibbs   +10 more
openalex   +1 more source

The relationship of pulmonary vascular resistance and compliance to pulmonary artery wedge pressure during submaximal exercise in healthy older adults

Journal of Physiology, 2016
S. Wright, J. Granton, S. Esfandiari, J. Goodman, S. Mak   +4 more
semanticscholar   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source