Results 81 to 90 of about 64,388 (220)

Real‐world outcomes of aflibercept 8 mg in patients previously treated for neovascular age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age‐related macular degeneration (nAMD). Methods This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti‐VEGF therapies at Sahlgrenska University Hospital between February 2024 and ...
Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund   +5 more
wiley   +1 more source

Effect of high‐intensity interval exercise on metformin pharmacokinetics in healthy men, assessed through a population pharmacokinetic model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Metformin and exercise are first‐line therapies for prediabetes and type 2 diabetes. However, it is unclear whether the combination of metformin and exercise is synergistic or antagonistic. The aim of this study was to investigate the effect of exercise on metformin pharmacokinetics and help clarify the contradictory ...
Stefanos Nikolaidis, Ioannis Kosmidis, Stylianos Papadopoulos, Artemis Lioupi, Marita Gandanidou, Helen Gika, Aristides Dokoumetzidis, Georgios Theodoridis, Vassilis Mougios   +8 more
wiley   +1 more source

A New X-Ray Census of Rotation Powered Pulsars

The Astrophysical Journal
To date, over 4000 pulsars have been detected. In this study, we identify 231 X-ray counterparts of Australia Telescope National Facility (ATNF) pulsars by performing a spatial cross match across the Chandra, XMM-Newton observational catalogs.
Yu-Jing Xu, Han-Long Peng, Shan-Shan Weng, Xiao Zhang, Ming-Yu Ge   +4 more
doaj   +1 more source

Limitations in timing precision due to single-pulse shape variability in millisecond pulsars [PDF]

, 2014
High-sensitivity radio-frequency observations of millisecond pulsars usually show stochastic, broad-band, pulse-shape variations intrinsic to the pulsar emission process.
R. Shannon, S. Osłowski, S. Osłowski, S. Dai, S. Dai, M. Bailes, G. Hobbs, R. Manchester, W. Straten, C. Raithel, V. Ravi, V. Ravi, L. Toomey, N. Bhat, S. Burke-Spolaor, W. Coles, M. Keith, M. Kerr, Y. Levin, J. Sarkissian, J. Wang, L. Wen, Xingjiang Zhu   +22 more
semanticscholar   +1 more source

Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders

Epilepsia, EarlyView.
Abstract Objective The BRSK1 gene encodes brain‐specific serine/threonine kinase 1 (also known as SAD‐B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitter release, mitochondrial dynamics, and neuronal maturation.
Qi Zhang, Hiroshi Yamanaka, Ping Li, Yingfeng Li, Tian Luo, Miao Xia, Ting Liu, Xueyan Liu, Qing Lu, Bin Yang, Fan He, Kaixian Du, Yousheng Shu, Bo Peng, Yong‐hui Jiang, Yi Wang   +15 more
wiley   +1 more source

Challenges in explaining the Galactic Center gamma-ray excess with millisecond pulsars [PDF]

, 2014
Millisecond pulsars have been discussed as a possible source of the gamma-ray excess observed from the region surrounding the Galactic Center. With this in mind, we use the observed population of bright low-mass X-ray binaries to estimate the number of ...
I. Cholis, D. Hooper, T. Linden
semanticscholar   +1 more source

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB‐inhibitor‐induced phenotypes

The FEBS Journal, EarlyView.
Whole‐organism phosphoproteomics after ErbB inhibitor treatment was assessed in zebrafish embryos. Differential signaling was uncovered after treatments with more selective ErbB inhibitors and pan‐ErbB inhibitors, despite similar neurological and myocardial phenotypes.
Katri Vaparanta, Zejia Song, Iman Farahani, Anne Jokilammi, Johannes Merilahti, Johanna Örling, Noora Virtanen, Pekka Haapaniemi, Cecilia Sahlgren, Klaus Elenius, Ilkka Paatero   +10 more
wiley   +1 more source

Efficiency of Nonthermal Pulsed Emission from Eight MeV Pulsars

The Astrophysical Journal
We report on the properties of pulsed X-ray emission from eight MeV pulsars using XMM-Newton, NICER, NuSTAR, and HXMT data. For five of the eight MeV pulsars, the X-ray spectra can be fit by a broken power-law model with a break energy of ∼5–10 keV.
J. Takata, H.-H. Wang, L. C.-C. , Lin, S. Kisaka   +3 more
doaj   +1 more source

The LOFAR pilot surveys for pulsars and fast radio transients [PDF]

, 2014
We have conducted two pilot surveys for radio pulsars and fast transients with the Low-Frequency Array (LOFAR) around 140 MHz and here report on the first low-frequency fast-radio burst limit and the discovery of two new pulsars.
T. Coenen, J. V. Leeuwen, J. Hessels, B. Stappers, V. Kondratiev, A. Alexov, R. Breton, A. Bilous, S. Cooper, H. Falcke, H. Falcke, R. Fallows, V. Gajjar, J. Grießmeier, T. Hassall, A. Karastergiou, E. Keane, M. Kramer, M. Kuniyoshi, A. Noutsos, S. Osłowski, S. Osłowski, M. Pilia, M. Serylak, C. Schrijvers, C. Sobey, S. Veen, J. Verbiest, P. Weltevrede, S. Wijnholds, K. Zagkouris, A. V. Amesfoort, James M. Anderson, A. Asgekar, I. Avruch, M. Bell, M. Bentum, G. Bernardi, P. Best, A. Bonafede, F. Breitling, J. Broderick, M. Brüggen, H. Butcher, B. Ciardi, A. Corstanje, A. Deller, S. Duscha, J. Eislöffel, R. Fender, C. Ferrari, W. Frieswijk, M. Garrett, F. Gasperin, E. D. Geus, A. Gunst, J. Hamaker, G. Heald, M. Hoeft, A. Horst, E. Juette, G. Kuper, C. Law, C. Law, G. Mann, R. McFadden, D. McKay-Bukowski, D. McKay-Bukowski, J. McKean, H. Munk, E. Orrú, H. Paas, M. Pandey-Pommier, A. Polatidis, W. Reich, A. Renting, H. Röttgering, A. Rowlinson, A. Scaife, D. Schwarz, J. Sluman, O. Smirnov, J. Swinbank, M. Tagger, Y. Tang, C. Tasse, S. Thoudam, C. Toribio, R. Vermeulen, C. Vocks, R. V. Weeren, O. Wucknitz, P. Zarka, A. Zensus   +93 more
semanticscholar   +1 more source

Soybean Inositol Polyphosphate 5‐Phosphatase 8 Confers Salt Tolerance by Reducing Sodium Influx Through Inositol 1,4,5‐Trisphosphate Signalling

Plant, Cell &Environment, EarlyView.
ABSTRACT Evidence suggests that the metabolism of inositol and its derivatives may be involved in various biological processes including salt tolerance, but there has been limited understanding. Ectopic expression of Gs5PTase8, an inositol polyphosphate 5‐phosphatase cloned from wild soybean (Glycine soja), significantly enhanced salt tolerance in ...
Qi Jia, Yuan Chen, Defeng Kong, Hanyu Fan, Song Sun, Yuhang Liu, Jiahui Fu, Man‐Wah Li, Fuk‐Ling Wong, Qinghua Li, Kangjing Liang, Hon‐Ming Lam, Wen‐Xiong Lin   +12 more
wiley   +1 more source